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glucose-measurment
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Determination of heavy metal ions by an amperometric biosensor based on glucose oxidase immobilized onto single-walled carbon nanotubes/Nile blue nanocomposite
, Article Journal of the Iranian Chemical Society ; Volume 15, Issue 8 , 2018 , Pages 1765-1774 ; 1735207X (ISSN) ; Sabzi, R. E ; Borghei, S. M ; Sharif University of Technology
Springer Verlag
2018
Abstract
An enzymatic electrochemical biosensor was prepared based on glucose oxidase (GOD) immobilized on single-walled carbon nanotubes/Nile blue (Nb–SWCNTs) nanocomposite cross-linked with glutaraldehyde on graphite electrode. The function of glucose biosensor is based on the electrocatalytic reduction of H2O2 generated by the reaction of the enzyme with glucose molecules. The biosensor was characterized by Fourier transform infrared (FTIR) spectroscopy, emission scanning (FESEM), UV–Vis spectrometry, and voltammetric and amperometric methods. Parameters influencing the performance of the biosensor, namely pH and applied potential, were optimized. Inhibition was carried out for the detection of...
Fabrication of a microdialysis-based nonenzymatic microfluidic sensor for regular glucose measurement
, Article Sensors and Actuators, B: Chemical ; Volume 333 , 2021 ; 09254005 (ISSN) ; Saidi, M. S ; Shahrokhian, S ; Hosseini, H ; Kazemzadeh Hannani, S ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Microdialysis-based continuous glucose measuring systems are desirable candidates for accurate and biologically safe monitoring of glucose level in diabetic patients. However, it is necessary to improve these systems by utilizing highly reliable non-enzymatic sensors instead of enzymatic ones, while lowering the size and lessening the dialysis fluid consumption. Our purpose is to design an implantable integrated microfluidic device for regular nonenzymatic microdialysis-based glucose measurement. We report a novel nonenzymatic microfluidic glucose sensor based on Pt-Ni nanoparticles - multiwalled carbon nanotubes/screen-printed carbon electrode (Pt-Ni NPs-MWCNTs/SPE). Devised microfluidic...
Fabrication of Enzyme Biosensor for Heavy Metal Detection
, M.Sc. Thesis Sharif University of Technology ; Borghei, Mehdi (Supervisor) ; Sabzi, Reza (Supervisor)
Abstract
In this project identification of heavy metals has been studied by using glucose oxidase enzyme. Measurement of heavy metals such as mercury (II) nitrate, lead (II) nitrate and cadmium nitrate are based on inhibitory of glucose oxidase enzyme. To do this, two modified electrodes has stabilized on a graphite electrode. Nanocomposite of single wall carbon nanotube with Nile Blue is foundation of the first working electrode. Biological component of the electrode is glucose oxidase enzyme that bovine serum albumin and glutaraldehyde are helping enzyme in immobilization and these materials cause enzyme to cross link with the foundation. This biosensor has great stability and suitable linear...
Design of Low Frequency High Resolution Integrated Bioimpedance Meter
, M.Sc. Thesis Sharif University of Technology ; Atarodi, Mojtaba (Supervisor) ; Mehrany, Khashayar (Supervisor)
Abstract
This thesis activities, consists of three main parts. The first part is, manufacturing and optimization of the electrical part of blood glucose measurement devices, based on electrochemical sensors. In this part, design of blood glucose measurement systems based on two and three electrode electrochemical sensors are proceeded and the accuracy of the electrical block, is increased up to 1mg/dl according to sensor current range. The second part, is related to the design of different probes for blood electrical characteristics (impedance magnitude) measurements, at low frequencies. Measurements with these probes show, first the blood impedance magnitude range at low frequencies and moreover,...
Constructing and Investigation of the Electrochemical Behavior of Nanocomposite of Conducting Polymers on Copper Hydroxide Nanotubes; Application to Determination of Glucose
, M.Sc. Thesis Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
A novel amperometric non-enzymatic glucose (NEG) sensor is designed by a facile preparation method. It is made by electrodeposition of Cu clusters and converting them to Cu(OH)2 nanotubes (Cu(OH)2NTs) arrays along with thin-film electro-polymerized of spindle-shaped polypyrrole (PPy@Cu(OH)2NTs), which have been doped by using sodium Benzene-1,3- disulfonate as an anion dopant. The electrochemical performance of the modified electrode toward glucose detection is investigated by various electrochemical methods. Under the optimized conditions, a significant electrochemical response improvement is observed toward the electro-oxidation of glucose on the surface of PPy@Cu(OH)2NTs electrode...
Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement
, Article Biotechnology Reports ; Volume 34 , 2022 ; 2215017X (ISSN) ; Saidi, M. S ; Kazemzadeh Hannani, S ; Sharif University of Technology
Elsevier B.V
2022
Abstract
The aim of this paper is to design and numerically simulate the mass-transfer compartment and piezoelectric micropump of an implantable integrated microfluidic device for regular microdialysis-based nonenzymatic measurement of glucose level in diabetic patients. The device function is based on the process that the piezoelectric micropump pumps the dialysis fluid into the mass-transfer compartment microchannels, where the interstitial fluid (ISF) glucose diffusion into this dialysis fluid gives it a glucose content, then detected and measured in the sensor section. This diffusion takes place through the semipermeable membranes located in the microchannels at the base of the hollow...
Optimizing fuzzy logic controller for diabetes type I by genetic algorithm
, Article 2010 The 2nd International Conference on Computer and Automation Engineering, ICCAE 2010, 26 February 2010 through 28 February 2010, Singapore ; Volume 2 , 2010 , Pages 4-8 ; 9781424455850 (ISBN) ; Azizi, A ; Sharif University of Technology
2010
Abstract
Biological systems are highly nonlinear, and there is a significant amount of variability from one patient to another. A controller for drug infusion has to be able to achieve good performance for most of the potential patient population. These controllers are designed for the general population, as no knowledge is available before hand for each particular patient. This necessitates perforce an algorithm that will be able to compensate for the differences between individuals and external factors. Of the possibilities, fuzzy logic direct model reference adaptive control (DMRAC) is the choice for Insulin infusion control for diabetes type I as results presented herein. Safety and robustness...
Numerical simulation of a microfluidic system for regular glucose measurement
, Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 60-65 ; 9781728156637 (ISBN) ; Saidi, M. S ; Shahrokhian, S ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2019
Abstract
The aim of this research is to design an implantable integrated microfluidic system in order to regularly measure the glucose level in the human body, nonenzymatically, using the microdialysis method. The main compartments of this system are a micropump, array of hollow microneedles and an electrochemical sensor. At the base of the microneedles, there are located semipermeable membranes, that when the pumped dialysis fluid passes over them, the glucose of the interstitial fluid diffuses into the dialysis fluid and then, in the sensor section, it is measured nonenzymatically using the amperometry method. Both the arrangement of the miconeedles and the amount of the dialysis fluid flow are...