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glucose-metabolism
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Numerical Simulation of Glucose Metabolism and Hepatocyte Viability within a Microfluidic
, M.Sc. Thesis Sharif University of Technology ; Firoozabadi, Bahar (Supervisor)
Abstract
The advent of microfluidics as suitable environments for culturing cells is associated with some challenges such as shear stresses applied on the cells. In fact, hepatocytes lose their function as exposed to high shear stresses similar to other cell types. Moreover, among all factors needed for cell viability, feeding hepatocytes with adequate oxygen is of great importance due to their high demand for oxygen compared the other cells. In this thesis, different types of cultures including 2D and 3D has been used in order that shear stresses would be in allowed range and provision of hepatocytes with sufficient oxygen concentrations has been ensured as well. In addition to supplying hepatocytes...
Characterization of a microfluidic microbial fuel cell as a power generator based on a nickel electrode
, Article Biosensors and Bioelectronics ; Volume 79 , 2016 , Pages 327-333 ; 09565663 (ISSN) ; Yaghmaei, S ; Sharif University of Technology
Elsevier Ltd
2016
Abstract
This study reports the fabrication of a microfluidic microbial fuel cell (MFC) using nickel as a novel alternative for conventional electrodes and a non-phatogenic strain of Escherichia coli as the biocatalyst. The feasibility of a microfluidic MFC as an efficient power generator for production of bioelectricity from glucose and urea as organic substrates in human blood and urine for implantable medical devices (IMDs) was investigated. A maximum open circuit potential of 459mV was achieved for the batch-fed microfluidic MFC. During continuous mode operation, a maximum power density of 104Wm-3 was obtained with nutrient broth. For the glucose-fed microfluidic MFC, the maximum power density of...