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Fabrication and Characterization of Nanocomposite Bone Scaffold with Gradient Structure Based on Thermoplastic Starch
, M.Sc. Thesis Sharif University of Technology ; Bagheri, Reza (Supervisor)
Abstract
Tissue regeneration by bio-compatible/degradable scaffolds is one of the widely used approaches in the field of tissue engineering. In this study, a thermoplastic starch based nanocomposite scaffold with gradient structure was fabricated by unidirectional freeze drying method. To increase the stability of the scaffold in the aqueous media, PVA was added to starch solution. Then, the PVA and starch molecules were cross-linked by adding citric acid to the mixture. On the one hand, to improve the mechanical properties of the scaffold, and control its bio-degradability on the other, cellulose nano-fibers were employed. Also, the bioactivity of the scaffold was induced by using hydroxyapatite...
Fabrication and characterization of a starch-based nanocomposite scaffold with highly porous and gradient structure for bone tissue engineering
, Article Biomedical Physics and Engineering Express ; Volume 4, Issue 5 , 2018 ; 20571976 (ISSN) ; Eslamian, M ; Bagheri, R ; Sharif University of Technology
Institute of Physics Publishing
2018
Abstract
Starch based scaffolds are considered as promising biomaterials for bone tissue engineering. In this study, a highly porous starch/polyvinyl alcohol (PVA) based nanocomposite scaffold with a gradient pore structure was made by incorporating different bio-additives, including citric acid, cellulose nanofibers, and hydroxyapatite (HA) nanoparticles. The scaffold was prepared by employing unidirectional and cryogenic freeze-casting and subsequently freeze-drying methods. Fourier transform infrared (FTIR) spectroscopy confirmed the cross-linking of starch and PVA molecules through multiple esterification phenomenon in the presence of citric acid as a cross-linking agent. Field emission scanning...