Sharif Digital Repository

Transdermal drug delivery systems are products which are known to have ability to pass drugs through the skin and into the blood, so medicine effects appear as a result. During the past two decades, many scientists interested in drug delivery through the skin. Constant blood plasma level and avoiding first-pass metabolism are advantages of this system compared to oral and intravenous systems. The biggest problem in the development of these systems, is impermeability of Stratum corneum, the outermost layer of the epidermis. In this study, design and evaluation of in vitro transdermal drug delivery system for granisetron serve as treatment of nausea and vomiting was performed. For this...