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    Mathematical study of probe arrangement and nanoparticle injection effects on heat transfer during cryosurgery

    , Article Computers in Biology and Medicine ; Volume 66 , Nov , 2015 , Pages 113-119 ; 00104825 (ISSN) Mirkhalili, S. M ; Ramazani S. A. A ; Nazemidashtarjandi, S ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Blood vessels, especially large vessels have a greater thermal effect on freezing tissue during cryosurgery. Vascular networks act as heat sources in tissue, and cause failure in cryosurgery and reappearance of cancer. The aim of this study is to numerically simulate the effect of probe location and multiprobe on heat transfer distribution. Furthermore, the effect of nanoparticles injection is studied. It is shown that the small probes location near large blood vessels could help to reduce the necessary time for tissue freezing. Nanoparticles injection shows that the thermal effect of blood vessel in tissue is improved. Using Au, Ag and diamond nanoparticles have the most growth of ice ball...