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DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism
, Article BMC Genomics ; 2017 , Volume 18, Issue 1 ; 14712164 (ISSN) ; Gerovska, D ; Adachi, K ; Totonchi, M ; Pezeshk, H ; Taft, R. J ; Schöler, H. R ; Chitsaz, H ; Sadeghi, M ; Baharvand, H ; Araúzo Bravo, M. J ; Sharif University of Technology
Abstract
Background: DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between DNA methylation and H3K4me1, a chromatin hallmark of enhancers. Results: We investigated the relationship between DNA methylation and active chromatin marks through genome-wide correlations, and found anti-correlation between H3K4me1 and H3K4me3 enrichment at low and intermediate DNA methylation loci. We hypothesized "seesaw" dynamics between H3K4me1 and H3K4me3 in the low...