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hemoglobin-a
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The non-significant benefit of BCG vaccination for the treatment of iranian patients with type 1 diabetes up to 48 weeks: a controversial result
, Article Medical Journal of the Islamic Republic of Iran ; Volume 35, Issue 1 , 2021 , Pages 1-5 ; 10161430 (ISSN) ; Zarei, P ; Shakerian, B ; Babaei, M ; Mostafavi, A ; Modaressi, M ; Sharif University of Technology
Iran University of Medical Sciences
2021
Abstract
Background: There has been considerable interest in target immunotherapy in patients with diabetes. This study was designed to identify the effect of BCG vaccination in the treatment of Iranian patients with longstanding diabetes mellitus type 1. Methods: After approval of the cross-sectional study protocol by the ethics committee under number IRCT2017042919940N2, a total of 19 Iranian volunteers with diabetes mellitus type 1 completed this 48-month study. These patients received three 0.1 ml intradermal injections of BCG vaccination in weeks 0, 4 and 24. The serum level of glucose, HgbA1C and c-peptide was measured before and serially after the interventions. Insulin requirements were...
Design and fabrication of a centrifugal microfluidic disc including septum valve for measuring hemoglobin A1c in human whole blood using immunoturbidimetry method
, Article Talanta ; Volume 190 , 2018 , Pages 134-139 ; 00399140 (ISSN) ; Saadatmand, M ; Bakhtiari, M. R ; Eghbal, M ; Sharif University of Technology
Elsevier B.V
2018
Abstract
Diabetes mellitus is a global endemic with a rapidly increasing prevalence in both developing and developed countries. Recently, hemoglobin A1c has been recommended by the American Diabetes Associations as a possible substitute for fasting blood glucose for the diagnosis of diabetes, because it is an indicator of long-term glycemic control. Also, centrifugal microfluidic systems have good potential for use in the point of care testing systems. In this study, a centrifugal microfluidic disc was designed and manufactured to measure hemoglobin A1c in whole blood using an immunoturbidimetry based method. Also, a new passive valve, named septum valve, was presented to precisely control the entry...
Comparison between two different hemichromes of hemoglobins (HbA and HbS) induced by n-dodecyl trimethylammonium bromide: Chemometric study
, Article Colloids and Surfaces B: Biointerfaces ; Volume 63, Issue 2 , 2008 , Pages 183-191 ; 09277765 (ISSN) ; Parastar, H ; Jalali Heravi, M ; Chamani, J ; Chilaka, F. C ; Moosavi Movahedi, A. A ; Sharif University of Technology
2008
Abstract
The interaction of n-dodecyl trimethylammonium bromide (DTAB) with oxyhemoglobin A and oxyhemoglobin S is investigated using UV-visible absorption spectra and chemometric resolution techniques. Oxyhemoglobins (A and S) induced to partial oxidized form (ferrihemoglobin) by DTAB and finally transform to fully oxidized hemichrome. Hemichrome mole fractions of HbS are more than HbA because of more hydrophobic interaction of DTAB-HbS in second set of binding site relative to DTAB-HbA. The visible spectra between 500 and 650 nm are used for identifying the present components in solution because each species of hemoglobin has a specific spectrum in this region. The number of components and mole...