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Label-Free real-time detection of HBsAg using a QCM immunosensor
, Article Clinical Laboratory ; Volume 68, Issue 4 , 2022 , Pages 707-720 ; 14336510 (ISSN) ; Ghavidel, A ; Ahangari Cohan, R ; Hamidi Fard, M ; Khoobi, M ; Aghasadeghi, M ; Norouzian, D ; Sharif University of Technology
Verlag Klinisches Labor GmbH
2022
Abstract
Background: Hepatitis B virus surface antigen (HBsAg) is an important protein in both diagnosis and prevention of hepatitis B infection. In the current study, a piezoelectric immunosensor based on antibody-antigen interaction was designed to detect HBsAg. A quartz crystal microbalance system was employed to detect antibody-antigen interaction. Methods: At first, an oscillator was designed to measure the resonant frequency affected by the reactants using IC 74LVC1GX04. Antibody against HBsAg was immobilized on 10 MHz AT-cut quartz crystal. The surface modifications were monitored by atomic force microscopy (AFM) and contact angle measurements. Different concentrations of antibody were used...
Nonlinear adaptive control method for treatment of uncertain hepatitis B virus infection
, Article Biomedical Signal Processing and Control ; Volume 38 , 2017 , Pages 174-181 ; 17468094 (ISSN) ; Sharifi, M ; Tashakori, S ; Zohoor, H ; Sharif University of Technology
Abstract
In this paper, a nonlinear adaptive control method is presented for the treatment of the Hepatitis B Virus (HBV) infection. Nonlinear dynamics of the HBV, modeling uncertainties and three state variables (the numbers of uninfected and infected cells and free viruses) are taken into account. The proposed control law is designed for the antiviral drug input such that the number of free viruses and consequently the number of infected cells decrease to the desired values. An adaptation law is also presented to overcome modeling uncertainties by updating estimations of the system parameters during the treatment period. The stability of the process and convergence to desired state values are...
Robust control strategy for HBV treatment: Considering parametric and nonparametric uncertainties
, Article Control Applications for Biomedical Engineering Systems ; 2020 , Pages 127-147 ; Sharifi, M ; Falsafi, A ; Sharif University of Technology
Elsevier Inc
2020
Abstract
Hepatitis is one of the most perilous viral infectious diseases and many people suffer from it all around the world. In particular, hepatitis B is a terribly dangerous disease which may cause severe liver damage or cancer if it is not treated. Recently, several dynamic models have been developed from experimental studies for describing such diseases mathematically. The certainty of these dynamics models is questionable in realistic treatment processes. Thus, the modeling uncertainties should be considered in the dynamics, which necessitates employing robust control strategies capable to overcome these uncertainties. Accordingly, in this research, a control strategy is developed in order to...
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
, Article The Lancet Gastroenterology and Hepatology ; Volume 7, Issue 9 , 2022 , Pages 796-829 ; 24681253 (ISSN) ; Hiebert, L ; Han, H ; Ippolito, H ; Abbasi-Kangevari, M ; Abbasi-Kangevari, Z ; Abbastabar, H ; Abdoli, A ; Abubaker Ali, H ; Adane, M. M ; Adegboye, O. A ; Adnani, Q. E. S ; Advani, S. M ; Afzal, M. S ; Afzal, S ; Aghaie Meybodi, M ; Ahadinezhad, B ; Ahinkorah, B. O ; Ahmad, S ; Ahmad, T ; Ahmadi, S ; Ahmed, H ; Ahmed, M. B ; Rashid, T. A ; Akalu, G. T ; Aklilu, A ; Akram, T ; Al Hamad, H ; Alahdab, F ; Alem, A ; Alem, D. T ; Alhalaiqa, F. A. N ; Alhassan, R. K ; Ali, L ; Ali, M. A ; Alimohamadi, Y ; Alipour, V ; Alkhayyat, M ; Almustanyir, S ; Al-Raddadi, R. M ; Altawalah, H ; Amini, S ; Amu, H ; Ancuceanu, R ; Andrei, C. L ; Andrei, T ; Anoushiravani, A ; Ansar, A ; Anyasodor, A. E ; Arabloo, J ; Arab-Zozani, M ; Argaw, A. M ; Argaw, Z. G ; Arshad, M ; Artamonov, A. A ; Ashraf, T ; Atlaw, D ; Ausloos, F ; Ausloos, M ; Azadnajafabad, S ; Azangou-Khyavy, M ; Azari Jafari, A ; Azarian, G ; Bagheri, S ; Bahadory, S ; Baig, A. A ; Banach, M ; Barati, N ; Barrow, A ; Batiha, A.-M. M ; Bejarano Ramirez, D. F ; Belgaumi, U. I ; Berhie, A. Y ; Bhagat, D. S ; Bhardwaj, N ; Bhardwaj, P ; Bhattacharyya, K ; Bhojaraja, V. S ; Bijani, A ; Biondi, A ; Bodicha, B. B. A ; Bojia, H. A ; Boloor, A ; Bosetti, C ; Braithwaite, D ; Briko, N. I ; Butt, Z. A ; Cámera, L. A ; Chakinala, R. C ; Chakraborty, P. A ; Charan, J ; Chen, S ; Choi, J.-Y. J ; Choudhari, S. G ; Chowdhury, F. R ; Chu, D.-T ; Chung, S.-C ; Cortesi, P. A ; Cowie, B. C ; Culbreth, G. T ; Dadras, O ; Dai, X ; Dandona, L ; Dandona, R ; De La Hoz, F. P ; Debela, S. A ; Dedefo, M. G ; Demeke, F. M ; Demie, T. G. G ; Demissie, G. D ; Derbew Molla, M ; Desta, A. A ; Dhamnetiya, D ; Dhimal, M. L ; Dhimal, M ; Didehdar, M ; Doan, L.P ; Dorostkar, F ; Drake, T.M ; Eghbalian, F ; Ekholuenetale, M ; El Sayed, I ; El Sayed Zaki, M ; Elhadi, M ; Elmonem, M. A ; Elsharkawy, A ; Enany, S ; Enyew, D. B ; Erkhembayar, R ; Eskandarieh, S ; Esmaeilzadeh, F ; Ezzikouri, S ; Farrokhpour, H ; Fetensa, G ; Fischer, F ; Foroutan, M ; Gad, M. M ; Gaidhane, A. M ; Gaidhane, S ; Galles, N. C ; Gallus, S ; Gebremeskel, T. G ; Gebreyohannes, E. A ; Ghadiri, K ; Ghaffari, K ; Ghafourifard, M ; Ghamari, S.-H ; Ghashghaee, A ; Gholami, A ; Gholizadeh, A ; Gilani, A ; Goel, A ; Golechha, M ; Goleij, P ; Golinelli, D ; Gorini, G ; Goshu, Y. A ; Griswold, M. G ; Gubari, M. I. M ; Gupta, B ; Gupta, S ; Gupta, V. B ; Gupta, V. K ; Haddadi, R ; Halwani, R ; Hamid, S.S ; Hamidi, S ; Hanif, A ; Haque, S ; Harapan, H ; Hargono, A ; Hariri, S ; Hasaballah, A. I ; Hasan, S. M. M ; Hassanipour, S ; Hassankhani, H ; Hay, S. I ; Hayat, K ; Heidari, G ; Herteliu, C ; Heyi, D. Z ; Hezam, K ; Holla, R ; Hosseini, M. S ; Hosseini, M ; Hosseinzadeh, M ; Hostiuc, M ; Househ, M ; Huang, J ; Hussein, N. R ; Iavicoli, I ; Ibitoye, S. E ; Ilesanmi, O. S ; Ilic, I. M ; Ilic, M. D ; Irham, L. M ; Islam, J. Y ; Ismail, N. E ; Jacobsen, K. H ; Jadidi-Niaragh, F ; Javadi Mamaghani, A ; Jayaram, S ; Jayawardena, R ; Jebai, R ; Jha, R. P ; Joseph, N ; Joukar, F ; Kaambwa, B ; Kabir, A ; Kabir, Z ; Kalhor, R ; Kandel, H ; Kanko, T. K. T ; Kantar, R. S ; Karaye, I. M ; Kassa, B. G ; Kemp Bohan, P. M ; Keykhaei, M ; Khader, Y. S ; Khajuria, H ; Khan, G ; Khan, I. A ; Khan, J ; Khan, M. A ; Khanali, J ; Khater, A. M ; Khatib, M. N ; Khodadost, M ; Khoja, A. T ; Khosravizadeh, O ; Khubchandani, J ; Kim, G. R ; Kim, H ; Kim, M. S ; Kim, Y. J ; Kocarnik, J. M ; Kolahi, A. A ; Koteeswaran, R ; Kumar, G. A ; La Vecchia, C ; Lal, D. K ; Landires, I ; Lasrado, S ; Lazarus, J. V ; Ledda, C ; Lee, D. W ; Lee, S. W ; Lee, Y. Y ; Levi, M ; Li, J ; Lim, S. S ; Lobo, S. W ; Lopukhov, P. D ; Loureiro, J. A ; MacLachlan, J. H ; Magdy Abd El Razek, H ; Magdy Abd El Razek, M ; Majeed, A ; Makki, A ; Malekpour, M. R ; Malekzadeh, R ; Malik, A. A ; Mansour-Ghanaei, F ; Mansournia, M. A ; Martins Melo, F. R ; Matthews, P. C ; Mendoza, W ; Menezes, R.G ; Meretoja, T.J ; Mersha, A.G ; Mestrovic, T ; Miller, T. R ; Minh, L. H. N ; Mirica, A ; Mirmoeeni, S ; Mirrakhimov, E. M ; Misra, S ; Mithra, P ; Moazen, B ; Mohamadkhani, A ; Mohammadi, M ; Mohammed, S ; Moka, N ; Mokdad, A. H ; Moludi, J ; Momtazmanesh, S ; Monasta, L ; Moradi, G ; Moradzadeh, M ; Moradzadeh, R ; Moraga, P ; Mostafavi, E ; Mubarik, S ; Muniyandi, M ; Murray, C. J. L ; Naghavi, M ; Naimzada, M. D ; Narasimha Swamy, S ; Natto, Z. S ; Nayak, B. P ; Nazari, J ; Negoi, I ; Negru, S. M ; Nejadghaderi, S. A ; Neupane Kandel, S ; Nguyen, H. L. T ; Ngwa, C. H ; Niazi, R. K ; Nnaji, C. A ; Noubiap, J. J ; Nowroozi, A ; Nuñez- Samudio, V ; Oancea, B ; Ochir, C ; Odukoya, O. O ; Oh, I. H ; Olagunju, A. T ; Olakunde, B. O ; Omar Bali, A ; Omer, E ; Otstavnov, S. S ; Oumer, B ; Padubidri, J. R ; Pana, A ; Pandey, A ; Park, E. C ; Pashazadeh Kan, F ; Patel, U. K ; Paudel, U ; Petcu, I. R ; Piracha, Z. Z ; Pollok, R. C. G ; Postma, M. J ; Pourshams, A ; Poustchi, H ; Rabiee, M ; Rabiee, N ; Rafiei, A ; Rafiei, S ; Raghuram, P. M ; Rahman, M ; Rahmani, A. M ; Rahmawaty, S ; Rajesh, A ; Ranasinghe, P ; Rao, C. R ; Rao, S. J ; Rashidi, M ; Rashidi, M. M ; Rawaf, D. L ; Rawaf, S ; Rawassizadeh, R ; Rezaei, N ; Rezapour, A ; Rezazadeh Khadem, S ; Rodriguez, J. A. B ; Rwegerera, G. M ; Sabour, S ; Saddik, B ; Saeb, M. R ; Saeed, U ; Sahebkar, A ; Saif-Ur-Rahman, K. M ; Salahi, S ; Salimzadeh, H ; Sampath, C ; Samy, A. M ; Sanabria, J ; Sanmarchi, F ; Santric Milicevic, M. M ; Sarveazad, A ; Sathian, B ; Sawhney, M ; Seidu, A. A ; Sepanlou, S. G ; Seylani, A ; Shahabi, S ; Shaikh, M. A ; Shaker, E ; Shakhmardanov, M. Z ; Shannawaz, M ; Shenoy, S. M ; Shetty, J. K ; Shetty, P. H ; Shibuya, K ; Shin, J. I ; Shobeiri, P ; Sibhat, M. M ; Singh, A. D ; Singh, J. A ; Singh, S ; Skryabin, V. Y ; Skryabina, A. A ; Sohrabpour, A. A ; Song, S ; Tabaeian, S. P ; Tadesse, E. G ; Taheri, M ; Tampa, M ; Tan, K. K ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary...
Robust adaptive Lyapunov-based control of hepatitis B infection
, Article IET Systems Biology ; Volume 12, Issue 2 , April , 2018 , Pages 62-67 ; 17518849 (ISSN) ; Sharifi, M ; Tashakori, S ; Zohoor, H ; Sharif University of Technology
Institution of Engineering and Technology
2018
Abstract
A new robust adaptive controller is developed for the control of the hepatitis B virus (HBV) infection inside the body. The non-linear HBV model has three state variables: uninfected cells, infected cells and free viruses. A control law is designed for the antiviral therapy such that the volume of infected cells and the volume of free viruses are decreased to their desired values which are zero. One control input represents the efficiency of drug therapy in inhibiting viral production and the other control input represents the efficiency of drug therapy in blocking new infection. The proposed controller ensures the stability and robust performance in the presence of parametric and...
Metabolomics analysis of the saliva in patients with chronic hepatitis b using nuclear magnetic resonance: A pilot study
, Article Iranian Journal of Basic Medical Sciences ; Volume 22, Issue 9 , 2019 , Pages 1044-1049 ; 20083866 (ISSN) ; Mohamadkhani, A ; Chashmniam, S ; Shahnazari, P ; Amini, M ; Arjmand, B ; Malekzadeh, R ; Nobakht Motlagh Ghoochani, B. F ; Sharif University of Technology
Mashhad University of Medical Sciences
2019
Abstract
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify...
The field effect transistor DNA biosensor based on ITO nanowires in label-free hepatitis B virus detecting compatible with CMOS technology
, Article Biosensors and Bioelectronics ; Volume 105 , 15 May , 2018 , Pages 58-64 ; 09565663 (ISSN) ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
In this paper the field-effect transistor DNA biosensor for detecting hepatitis B virus (HBV) based on indium tin oxide nanowires (ITO NWs) in label free approach has been fabricated. Because of ITO nanowires intensive conductance and functional modified surface, the probe immobilization and target hybridization were increased strongly. The high resolution transmission electron microscopy (HRTEM) measurement showed that ITO nanowires were crystalline and less than 50 nm in diameter. The single-stranded hepatitis B virus DNA (SS-DNA) was immobilized as probe on the Au-modified nanowires. The DNA targets were measured in a linear concentration range from 1fM to 10 µM. The detection limit of...
Enhanced electrochemical activity of a hollow carbon sphere/polyaniline-based electrochemical biosensor for HBV DNA marker detection
, Article ACS Biomaterials Science and Engineering ; Volume 5, Issue 5 , 2019 , Pages 2587-2594 ; 23739878 (ISSN) ; Shahrokhian, S ; Panahi, S ; Sharif University of Technology
American Chemical Society
2019
Abstract
Herein, we present a novel, simple, and ultrasensitive electrochemical DNA (E-DNA) sensor based on hollow carbon spheres (HCS) decorated with polyaniline (PANI). A thiolated 21-mer oligonucleotide, characteristic of HBV DNA, is immobilized via electrodeposited gold nanoparticles on HCS-PANI. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) are used to characterize the electrochemical properties of the prepared nanocomposite. Scanning electron microscopy is employed to investigate the morphological texture of the fabricated modifier. An enhanced intrinsic signal of PANI is probed to evaluate the biosensing ability of the prepared...
Challenges and future prospects for the delivery of biologics: oral mucosal, pulmonary, and transdermal routes
, Article AAPS Journal ; Volume 19, Issue 3 , 2017 , Pages 652-668 ; 15507416 (ISSN) ; Fathe, K. R ; Brunaugh, A ; Ferrati, S ; Li, S ; Montenegro Nicolini, M ; Mousavikhamene, Z ; McConville, J. T ; Prausnitz, M. R ; Smyth, H. D. C ; Sharif University of Technology
Springer New York LLC
2017
Abstract
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers. While all these routes avoid transit through the...
Graphene-based nanomaterials in fighting the most challenging viruses and immunogenic disorders
, Article ACS Biomaterials Science and Engineering ; Volume 8, Issue 1 , 2022 , Pages 54-81 ; 23739878 (ISSN) ; Asadi, M ; Akhavan, O ; Sharif University of Technology
American Chemical Society
2022
Abstract
Viral diseases have long been among the biggest challenges for healthcare systems around the world. The recent Coronavirus Disease 2019 (COVID-19) pandemic is an example of how complicated the situation can get if we are not prepared to combat a viral outbreak in time, which brings up the need for quick and affordable biosensing platforms and vast knowledge of potential antiviral effects and drug/gene delivery opportunities. The same challenges have also existed for nonviral immunogenic disorders. Nanomedicine is considered a novel candidate for effectively overcoming these worldwide challenges. Among the versatile nanomaterials commonly used in biomedical applications, graphene has recently...