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    Nonlinear Adaptive Control of Treatment in a Basic Hepatitis B Virus Infection Model in the Presence of Uncertainties

    , M.Sc. Thesis Sharif University of Technology Aghajanzadeh, Omid (Author) ; Zohour, Hassan (Supervisor)
    Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) which affects the liver. Several dynamic models have been developed to mathematically describe the HBV infection and antiviral therapy. In this thesis, a nonlinear adaptive control strategy is developed for the treatment of the Hepatitis B Virus (HBV) infection inside a body. The considered nonlinear HBV model has three state variables, the numbers of uninfected and infected cells and free viruses. The proposed control law is designed for the antiviral drug input such that the number of free viruses per unit volume of the blood and consequently the number of infected cells decrease to some desired values. The... 

    Design and Development of Electrochemical DNA Nanobiosensors for Identification and Determination of Important Biomarkers

    , Ph.D. Dissertation Sharif University of Technology Salimian, Razieh (Author) ; Shahrokhian, Saeed (Supervisor) ; Kalhor, Hamid Reza (Co-Supervisor)
    The main purpose of this Ph.D. Thesis is to develop DNA-based biosensors using Label-free approaches applying simple, inexpensive and fast electrochemical techniques to measure the biological markers of cancer.In the first part, a simple protocol for detection of specific-sequence DNA is introduced. In this method carbon nanotube is used as a hybridization indicator. This label-free system provides the advantage of eliminating additional labeling procedure. As the signal enhances in the presence of MWCNT and decreases in the presence of target, the fabricated sensor is known as a signal-off device. The oxidation signal of Fe(CN)63-/4- is followed as an analytical signal to detect target... 

    Mathematical Models of the Interrelated Dynamics of Hepatitis D and B

    , M.Sc. Thesis Sharif University of Technology khosrotash, Masoud (Author) ; Hesaraki, Mahmoud (Supervisor)
    The hepatitis delta virus (HDV) is a rarest form of viral hepatitis, but has the worst outcomes for patients.It is a subviral satellite dependent on coinfection with hepatitis B (HBV) to replicate within the host liver.To date, there has been little to no modeling effort for HDV. Deriving and analyzing such a mathematicalmodel poses difficulty as it requires the inclusion of (HBV). Here we begin with a well-studied HBV modelfrom the literature and expand it to incorporate HDV. We investigate two models, one with and one withoutinfected hepatocyte replication. Additionally, we consider treatment by the drug lamivudine. Comparison of model simulations with experimental results of lamivudine...