Loading...
Search for:
hepatitis-c
0.01 seconds
Label-Free real-time detection of HBsAg using a QCM immunosensor
, Article Clinical Laboratory ; Volume 68, Issue 4 , 2022 , Pages 707-720 ; 14336510 (ISSN) ; Ghavidel, A ; Ahangari Cohan, R ; Hamidi Fard, M ; Khoobi, M ; Aghasadeghi, M ; Norouzian, D ; Sharif University of Technology
Verlag Klinisches Labor GmbH
2022
Abstract
Background: Hepatitis B virus surface antigen (HBsAg) is an important protein in both diagnosis and prevention of hepatitis B infection. In the current study, a piezoelectric immunosensor based on antibody-antigen interaction was designed to detect HBsAg. A quartz crystal microbalance system was employed to detect antibody-antigen interaction. Methods: At first, an oscillator was designed to measure the resonant frequency affected by the reactants using IC 74LVC1GX04. Antibody against HBsAg was immobilized on 10 MHz AT-cut quartz crystal. The surface modifications were monitored by atomic force microscopy (AFM) and contact angle measurements. Different concentrations of antibody were used...
Proposing a Control Strategy for Treatment of Hepatitis C Disease
, M.Sc. Thesis Sharif University of Technology ; Shahrokhi, Mohammad (Supervisor)
Abstract
Due to the importance of hepatitis disease, especially hepatitis C, from public health view point, this research aims to investigate and suggest an efficient medical therapy for this disease. First, available models are analyzed and the suitable one is chosen. Three controllers namely, fixed PI, adaptive PI and exact linearization control (GLC) are designed to control the hepatitis C disease using the drug efficacy as the manipulated variabel. Controller parameters are determined by the Genetic Algorithm (GA) and their performances are evaluated using the selected model. Uncertainties have been considerd in both model structure and parameters and controllers performances are investigated in...
Inspection of Inhibitory Effect of 5-Hydroxy-3(2H)-Pyridazinone Derivatives on Hepatitis C Virus Using Chemometric Methods
, M.Sc. Thesis Sharif University of Technology ; Jalali-Heravi, Mehdi (Supervisor)
Abstract
The derivatives of 5-Hydroxy-3(2H)-pyridazinone show inhibitory effects on hepatitis C virus. The aim of the present work was modeling and prediction of inhibitory effects of these derivatives (Log(1/EC50)) on this disease. In this research, a data set of 119 molecules of 5-Hydroxy-3(2H)-pyridazinone derivatives that have inhibitory effect on hepatitis C virus was selected. The MLR model was generated using SPSS package. Five important descriptors were selected applying stepwise variable selection technique. These descriptors selected through 1207 descriptors that were calculated for all molecules in data set. Best model with high R2 and F values and low RMSE was selected for the...
Proposing a Stable Treatment Strategy for Hepatitis C
, Ph.D. Dissertation Sharif University of Technology ; Shahrokhi, Mohammad (Supervisor)
Abstract
The purpose of this study is to propose a stable treatment strategy for hepatitis C infection by considering several practical limitations of the treatment and using control theories. First, hepatitis C disease and its transmission, diagnosis, and treatment methods have been introduced. Then, the mathematical models of hepatitis C dynamics in the body have been presented, and their ability in predicting the observed clinical behaviors of the patients has been studied. Thereafter, the extended versions of these models by considering pharmacokinetics/dynamics equations of the drugs have been proposed to have a more realistic mathematical model. After that, the practical features of the disease...
Observer-based controller for treatment of hepatitis C infection using fractional order model
, Article Mathematical Methods in the Applied Sciences ; Volume 45, Issue 17 , 2022 , Pages 10689-10709 ; 01704214 (ISSN) ; Shahrokhi, M ; Pishro, A ; Sharif University of Technology
John Wiley and Sons Ltd
2022
Abstract
In this study, a stable observer-based feedback controller has been designed for treatment of hepatitis C infectious disease under interferon (IFN) therapy. In order to consider the memory behavior and uncertain nature of this biological system, an unknown dynamics fractional-order (FO) model has been utilized for describing the interactions between the healthy cells, infected cells, and hepatitis C virus (HCV). To cope with unknown dynamics, the fuzzy logic system (FLS) has been utilized. Limitation of the drug efficacy due to its negative side effects has been taken into account as an input saturation. In order to estimate the unknown states which are required for treatment, a full-order...
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
, Article The Lancet Gastroenterology and Hepatology ; Volume 7, Issue 9 , 2022 , Pages 796-829 ; 24681253 (ISSN) ; Hiebert, L ; Han, H ; Ippolito, H ; Abbasi-Kangevari, M ; Abbasi-Kangevari, Z ; Abbastabar, H ; Abdoli, A ; Abubaker Ali, H ; Adane, M. M ; Adegboye, O. A ; Adnani, Q. E. S ; Advani, S. M ; Afzal, M. S ; Afzal, S ; Aghaie Meybodi, M ; Ahadinezhad, B ; Ahinkorah, B. O ; Ahmad, S ; Ahmad, T ; Ahmadi, S ; Ahmed, H ; Ahmed, M. B ; Rashid, T. A ; Akalu, G. T ; Aklilu, A ; Akram, T ; Al Hamad, H ; Alahdab, F ; Alem, A ; Alem, D. T ; Alhalaiqa, F. A. N ; Alhassan, R. K ; Ali, L ; Ali, M. A ; Alimohamadi, Y ; Alipour, V ; Alkhayyat, M ; Almustanyir, S ; Al-Raddadi, R. M ; Altawalah, H ; Amini, S ; Amu, H ; Ancuceanu, R ; Andrei, C. L ; Andrei, T ; Anoushiravani, A ; Ansar, A ; Anyasodor, A. E ; Arabloo, J ; Arab-Zozani, M ; Argaw, A. M ; Argaw, Z. G ; Arshad, M ; Artamonov, A. A ; Ashraf, T ; Atlaw, D ; Ausloos, F ; Ausloos, M ; Azadnajafabad, S ; Azangou-Khyavy, M ; Azari Jafari, A ; Azarian, G ; Bagheri, S ; Bahadory, S ; Baig, A. A ; Banach, M ; Barati, N ; Barrow, A ; Batiha, A.-M. M ; Bejarano Ramirez, D. F ; Belgaumi, U. I ; Berhie, A. Y ; Bhagat, D. S ; Bhardwaj, N ; Bhardwaj, P ; Bhattacharyya, K ; Bhojaraja, V. S ; Bijani, A ; Biondi, A ; Bodicha, B. B. A ; Bojia, H. A ; Boloor, A ; Bosetti, C ; Braithwaite, D ; Briko, N. I ; Butt, Z. A ; Cámera, L. A ; Chakinala, R. C ; Chakraborty, P. A ; Charan, J ; Chen, S ; Choi, J.-Y. J ; Choudhari, S. G ; Chowdhury, F. R ; Chu, D.-T ; Chung, S.-C ; Cortesi, P. A ; Cowie, B. C ; Culbreth, G. T ; Dadras, O ; Dai, X ; Dandona, L ; Dandona, R ; De La Hoz, F. P ; Debela, S. A ; Dedefo, M. G ; Demeke, F. M ; Demie, T. G. G ; Demissie, G. D ; Derbew Molla, M ; Desta, A. A ; Dhamnetiya, D ; Dhimal, M. L ; Dhimal, M ; Didehdar, M ; Doan, L.P ; Dorostkar, F ; Drake, T.M ; Eghbalian, F ; Ekholuenetale, M ; El Sayed, I ; El Sayed Zaki, M ; Elhadi, M ; Elmonem, M. A ; Elsharkawy, A ; Enany, S ; Enyew, D. B ; Erkhembayar, R ; Eskandarieh, S ; Esmaeilzadeh, F ; Ezzikouri, S ; Farrokhpour, H ; Fetensa, G ; Fischer, F ; Foroutan, M ; Gad, M. M ; Gaidhane, A. M ; Gaidhane, S ; Galles, N. C ; Gallus, S ; Gebremeskel, T. G ; Gebreyohannes, E. A ; Ghadiri, K ; Ghaffari, K ; Ghafourifard, M ; Ghamari, S.-H ; Ghashghaee, A ; Gholami, A ; Gholizadeh, A ; Gilani, A ; Goel, A ; Golechha, M ; Goleij, P ; Golinelli, D ; Gorini, G ; Goshu, Y. A ; Griswold, M. G ; Gubari, M. I. M ; Gupta, B ; Gupta, S ; Gupta, V. B ; Gupta, V. K ; Haddadi, R ; Halwani, R ; Hamid, S.S ; Hamidi, S ; Hanif, A ; Haque, S ; Harapan, H ; Hargono, A ; Hariri, S ; Hasaballah, A. I ; Hasan, S. M. M ; Hassanipour, S ; Hassankhani, H ; Hay, S. I ; Hayat, K ; Heidari, G ; Herteliu, C ; Heyi, D. Z ; Hezam, K ; Holla, R ; Hosseini, M. S ; Hosseini, M ; Hosseinzadeh, M ; Hostiuc, M ; Househ, M ; Huang, J ; Hussein, N. R ; Iavicoli, I ; Ibitoye, S. E ; Ilesanmi, O. S ; Ilic, I. M ; Ilic, M. D ; Irham, L. M ; Islam, J. Y ; Ismail, N. E ; Jacobsen, K. H ; Jadidi-Niaragh, F ; Javadi Mamaghani, A ; Jayaram, S ; Jayawardena, R ; Jebai, R ; Jha, R. P ; Joseph, N ; Joukar, F ; Kaambwa, B ; Kabir, A ; Kabir, Z ; Kalhor, R ; Kandel, H ; Kanko, T. K. T ; Kantar, R. S ; Karaye, I. M ; Kassa, B. G ; Kemp Bohan, P. M ; Keykhaei, M ; Khader, Y. S ; Khajuria, H ; Khan, G ; Khan, I. A ; Khan, J ; Khan, M. A ; Khanali, J ; Khater, A. M ; Khatib, M. N ; Khodadost, M ; Khoja, A. T ; Khosravizadeh, O ; Khubchandani, J ; Kim, G. R ; Kim, H ; Kim, M. S ; Kim, Y. J ; Kocarnik, J. M ; Kolahi, A. A ; Koteeswaran, R ; Kumar, G. A ; La Vecchia, C ; Lal, D. K ; Landires, I ; Lasrado, S ; Lazarus, J. V ; Ledda, C ; Lee, D. W ; Lee, S. W ; Lee, Y. Y ; Levi, M ; Li, J ; Lim, S. S ; Lobo, S. W ; Lopukhov, P. D ; Loureiro, J. A ; MacLachlan, J. H ; Magdy Abd El Razek, H ; Magdy Abd El Razek, M ; Majeed, A ; Makki, A ; Malekpour, M. R ; Malekzadeh, R ; Malik, A. A ; Mansour-Ghanaei, F ; Mansournia, M. A ; Martins Melo, F. R ; Matthews, P. C ; Mendoza, W ; Menezes, R.G ; Meretoja, T.J ; Mersha, A.G ; Mestrovic, T ; Miller, T. R ; Minh, L. H. N ; Mirica, A ; Mirmoeeni, S ; Mirrakhimov, E. M ; Misra, S ; Mithra, P ; Moazen, B ; Mohamadkhani, A ; Mohammadi, M ; Mohammed, S ; Moka, N ; Mokdad, A. H ; Moludi, J ; Momtazmanesh, S ; Monasta, L ; Moradi, G ; Moradzadeh, M ; Moradzadeh, R ; Moraga, P ; Mostafavi, E ; Mubarik, S ; Muniyandi, M ; Murray, C. J. L ; Naghavi, M ; Naimzada, M. D ; Narasimha Swamy, S ; Natto, Z. S ; Nayak, B. P ; Nazari, J ; Negoi, I ; Negru, S. M ; Nejadghaderi, S. A ; Neupane Kandel, S ; Nguyen, H. L. T ; Ngwa, C. H ; Niazi, R. K ; Nnaji, C. A ; Noubiap, J. J ; Nowroozi, A ; Nuñez- Samudio, V ; Oancea, B ; Ochir, C ; Odukoya, O. O ; Oh, I. H ; Olagunju, A. T ; Olakunde, B. O ; Omar Bali, A ; Omer, E ; Otstavnov, S. S ; Oumer, B ; Padubidri, J. R ; Pana, A ; Pandey, A ; Park, E. C ; Pashazadeh Kan, F ; Patel, U. K ; Paudel, U ; Petcu, I. R ; Piracha, Z. Z ; Pollok, R. C. G ; Postma, M. J ; Pourshams, A ; Poustchi, H ; Rabiee, M ; Rabiee, N ; Rafiei, A ; Rafiei, S ; Raghuram, P. M ; Rahman, M ; Rahmani, A. M ; Rahmawaty, S ; Rajesh, A ; Ranasinghe, P ; Rao, C. R ; Rao, S. J ; Rashidi, M ; Rashidi, M. M ; Rawaf, D. L ; Rawaf, S ; Rawassizadeh, R ; Rezaei, N ; Rezapour, A ; Rezazadeh Khadem, S ; Rodriguez, J. A. B ; Rwegerera, G. M ; Sabour, S ; Saddik, B ; Saeb, M. R ; Saeed, U ; Sahebkar, A ; Saif-Ur-Rahman, K. M ; Salahi, S ; Salimzadeh, H ; Sampath, C ; Samy, A. M ; Sanabria, J ; Sanmarchi, F ; Santric Milicevic, M. M ; Sarveazad, A ; Sathian, B ; Sawhney, M ; Seidu, A. A ; Sepanlou, S. G ; Seylani, A ; Shahabi, S ; Shaikh, M. A ; Shaker, E ; Shakhmardanov, M. Z ; Shannawaz, M ; Shenoy, S. M ; Shetty, J. K ; Shetty, P. H ; Shibuya, K ; Shin, J. I ; Shobeiri, P ; Sibhat, M. M ; Singh, A. D ; Singh, J. A ; Singh, S ; Skryabin, V. Y ; Skryabina, A. A ; Sohrabpour, A. A ; Song, S ; Tabaeian, S. P ; Tadesse, E. G ; Taheri, M ; Tampa, M ; Tan, K. K ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary...
Graphene-based nanomaterials in fighting the most challenging viruses and immunogenic disorders
, Article ACS Biomaterials Science and Engineering ; Volume 8, Issue 1 , 2022 , Pages 54-81 ; 23739878 (ISSN) ; Asadi, M ; Akhavan, O ; Sharif University of Technology
American Chemical Society
2022
Abstract
Viral diseases have long been among the biggest challenges for healthcare systems around the world. The recent Coronavirus Disease 2019 (COVID-19) pandemic is an example of how complicated the situation can get if we are not prepared to combat a viral outbreak in time, which brings up the need for quick and affordable biosensing platforms and vast knowledge of potential antiviral effects and drug/gene delivery opportunities. The same challenges have also existed for nonviral immunogenic disorders. Nanomedicine is considered a novel candidate for effectively overcoming these worldwide challenges. Among the versatile nanomaterials commonly used in biomedical applications, graphene has recently...