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hepatocyte
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Numerical Simulation of Glucose Metabolism and Hepatocyte Viability within a Microfluidic
, M.Sc. Thesis Sharif University of Technology ; Firoozabadi, Bahar (Supervisor)
Abstract
The advent of microfluidics as suitable environments for culturing cells is associated with some challenges such as shear stresses applied on the cells. In fact, hepatocytes lose their function as exposed to high shear stresses similar to other cell types. Moreover, among all factors needed for cell viability, feeding hepatocytes with adequate oxygen is of great importance due to their high demand for oxygen compared the other cells. In this thesis, different types of cultures including 2D and 3D has been used in order that shear stresses would be in allowed range and provision of hepatocytes with sufficient oxygen concentrations has been ensured as well. In addition to supplying hepatocytes...
Theoretical and Experimental Simulation of Hepatic Cells and their Functionalities On-a-chip
, Ph.D. Dissertation Sharif University of Technology ; Firoozabadi, Bahar (Supervisor) ; Firoozbakhsh, Keikhosrow (Supervisor)
Abstract
Liver is the largest internal organ of the human body which serves many vital functionalities. Recently, liver-on-a-chip systems have been used to model some of the vital liver specific-functions and to investigate its related diseases. The purpose of the present study was simulation of some of these liver specific functionalities on-a-chip and using the obtained results in predicting hepatocellular functionalities i.e. production of some metabolites and modeling some of the liver-related diseases which have been done numerically and experimentally. Numerical simulations have been developed in two-dimensional and three-dimensional forms. In the 2D simulation, the governing equations i.e....