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high-throughput-determination
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Quantification of in Vitro Drug Effects on COVID-19 through Analysis of Cellular Morphological Features
, M.Sc. Thesis Sharif University of Technology ; Rohban, Mohammad Hossein (Supervisor) ; Sharifi Zarchi, Ali (Supervisor)
Abstract
The epidemic of Covid 19 has killed millions of people worldwide. Despite the efforts of scientists around the world, there is still no cure for this disease. Approval of newly designed drugs due to clinical trial periods is time-consuming and costly. For this reason, in the current emergency situation, it is important to have a solution for screening available approved drugs in order to find effective substances for this disease.High-throughput assays are a good option for such problems. In this field of research, image-based high-throughput assays are amongst the most effective and cost-effective methods that help quantify the response of treated cells by measuring cell...
High-Throughput Determination of Pesticide Residues by Solid-Phase Microextraction and Micro-Solid Phase Extraction on 96-Well Plate
, Ph.D. Dissertation Sharif University of Technology ; Bagheri, Habib (Supervisor) ; Es-haghi, Ali ($item.subfieldsMap.e)
Abstract
Novel high-throughput device and their applications as the microextraction systems for pesticide multiresidue determination is the centre of this research. 96 extracting unit based on solid phase microextraction and micro-Solid phase extraction were constructed and applied for high-throughput extraction.
In the first work, a high-throughput SPME on 96-well plate together with gas chromatography-mass spectrometry was developed for the determination of pesticide residues in cucumber samples. A home-made Teflon block consisting ninety-six holes was constructed to 96 SPME fibers being positioned in. SPME fibers consisted of stainless steel rods with a 1.0 cm polydimethylsiloxane tubing...
In the first work, a high-throughput SPME on 96-well plate together with gas chromatography-mass spectrometry was developed for the determination of pesticide residues in cucumber samples. A home-made Teflon block consisting ninety-six holes was constructed to 96 SPME fibers being positioned in. SPME fibers consisted of stainless steel rods with a 1.0 cm polydimethylsiloxane tubing...
Numerical Investigation of Droplet Generation in a Microfluidic Flow-Focusing Junction Aiming High-Throughput Droplet Generation
, M.Sc. Thesis Sharif University of Technology ; Taghipoor, Mojtaba (Supervisor) ; Hosseini, Vahid (Supervisor)
Abstract
Droplet microfluidic platform generates monodisperse droplets in a desired size through immiscible multiphase flows inside microchannels. Droplets are individual reactor and can be used for bio(chemical) analyses. Also, for materials fabrication, droplet microfluidics offers a versatile platform for generation of nano- or micro-sized particles and microcapsules that are widely used in drug delivery. In addition to the monodispersity, high-throughput generation is also necessary in many applications. Therefore, droplets must be formed in stable regimes (dripping and squeezing) in the highest possible frequency. In this study, the flow-focusing geometry, which is the most common geometry in...