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Biodegradable polyurethane acrylate/HEMA-grafted nanodiamond composites with bone regenerative potential applications: Structure, mechanical properties and biocompatibility
, Article RSC Advances ; Volume 6, Issue 11 , 2016 , Pages 8743-8755 ; 20462069 (ISSN) ; Shojaei, A ; Abdekhodaie, M. J ; Sharif University of Technology
Royal Society of Chemistry
Abstract
The present study demonstrates HEMA-grafted nanodiamond (ND-HEMA)/acrylate-terminated polyurethane-acrylate diluents (APUA) composites as promising materials for bone implant applications. Neat APUA and APUA composites containing ND-HEMA at different loadings up to 2 wt% were prepared by an in situ polymerization method. Morphological analysis demonstrated that ND-HEMAs were actually in the form of tightly bound aggregates which led to formation of big agglomerates at a concentration of 2 wt%. It was also suggested that ND-HEMAs were preferentially localized in the continuous soft domain of APUA; however it interacted by both soft and hard domains. Moreover, ND-HEMAs caused considerable...
Nanodiamonds for surface engineering of orthopedic implants: Enhanced biocompatibility in human osteosarcoma cell culture
, Article Diamond and Related Materials ; Volume: 40 , 2013 , Pages: 107-114 ; 09259635 (ISSN) ; Shokrgozar, M. A ; Mehrjoo, M ; Tamjid, E ; Simchi, A ; Sharif University of Technology
2013
Abstract
Recently, nanodiamonds have attracted interest in biomedical applications such as drug delivery, targeted cancer therapies, fabrication of tissue scaffolds, and biosensors. We incorporated diamond nanoparticles in alginate-bioactive glass films by electrophoretic process to prepare functional coatings for biomedical implants. Turbidity examination by time-resolved laser transmittance measurement revealed that a stable multi-component aqueous suspension of alginate, bioactive glass and diamond particles could be obtained at concentrations of 0.6, 1.3, and 0.65 g/l, respectively. Uniform films with ~ 5 μm thickness were deposited on 316 stainless steel foils by employing constant field...
Physicochemical and biological properties of electrodeposited graphene oxide/chitosan films with drug-eluting capacity
, Article Carbon ; Volume 84, Issue C , April , 2015 , Pages 91-102 ; 00086223 (ISSN) ; Ramezani Farani, M ; Dehghani, M ; Tamjid, E ; Simchi, A ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
In this study, novel graphene oxide/chitosan nanocomposite coatings with long term drugeluting potential are presented. The coatings are fabricated by the facile and reproducible electrophoretic deposition technique. Analysis of the prepared films shows that the graphene oxide nanosheets are exfoliated in the chitosan matrix. Fourier-transform infrared spectrometry reveals polymer attachment to the carboxylic bonds of graphene oxide, providing a strong interaction and exfoliation of the nanolayers. In vitro viability assay by human osteosarcoma cells (MG-63) demonstrates that the nanocomposite films are highly biocompatible up to 30 wt% graphene oxide, but at higher concentrations a slight...