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    Cytotoxicity of carbon nanotube/polycitric acid hybrid nanomaterials

    , Article Iranian Polymer Journal (English Edition) ; Vol. 23, issue. 3 , 2014 , pp. 195-201 ; ISSN: 10261265 Adeli, M ; Alavidjeh, M. S ; Mohammadifar, E ; Sharif University of Technology
    Polycitric acid was conjugated onto the surface of carbon nanotubes (CNTs), and hybrid nanomaterials containing CNT axis and polycitric acid branches that were highly soluble in aqueous solutions were synthesized. In this work, pristine MWCNTs were opened and functionalized through treatment with acid, then polycitric acid was covalently grafted onto their surface by the "grafting from" approach based on polycondensation of citric acid in the melting state. The chemical structure, morphology, thermal properties and size of MWCNT-g-PCA hybrid materials were investigated by IR, 13C NMR, 1H NMR, TEM, TGA, DSC and DLS. To investigate the biocompatibility of the synthesized hybrid nanomaterials... 

    Supramolecular hybrid nanomaterials as drug delivery systems

    , Article Supramolecular Chemistry ; Volume 23, Issue 6 , Apr , 2011 , Pages 411-418 ; 10610278 (ISSN) Adeli, M ; Hakimpour, F ; Sagvand, M ; Jaafari, M. R ; Kabiri, R ; Moshari, Z ; Sharif University of Technology
    Highly fluorescent and water-soluble cadmium selenide quantum dots (QDs) functionalised by thio-cyclodextrin (HS-CD) and mercaptoacetic acid (MAA) as surface coating agents (QDs-CD-MAA) were synthesised successfully. The synthesised hybrid nanomaterials, QDs-CD-MAA, were able to form water-soluble complexes with paclitaxel and folic acid. QDs and their complexes were characterised by usual spectroscopy and microscopy methods. Size and morphology of functionalised QDs were dependent on their capping agents and guest molecules. Short-term in vitro cytotoxicity tests on mouse tissue connective fibroblast adhesive cells (L929) showed that conjugation of CD molecules onto the surface of QDs... 

    Investigating the rheological properties of nanofluids of water/hybrid nanostructure of spherical silica/MWCNT

    , Article Thermochimica Acta ; Volume 578 , 20 February , 2014 , Pages 53-58 ; ISSN: 00406031 Baghbanzadeh, M ; Rashidi, A ; Soleimanisalim, A. H ; Rashtchian, D ; Sharif University of Technology
    Regarding the importance of rheological properties of water based drilling fluids, the effects of silica nanospheres, multiwall carbon nanotubes (MWCNTs) and two types of their hybrid, i.e. H1 (80 wt.% silica nanosphere/20 wt.% MWCNT) and H2 (50 wt.% silica nanosphere/50 wt.% MWCNT) on the viscosity and density of distilled water were investigated. According to the results, viscosity and density of the nanofluids increased with the concentration, while they were reduced by increasing the temperature. At high concentrations, the least increase in the viscosity of distilled water by adding the nanomaterials is related to H2 (8.2% increase at 1.0 wt.%). Likewise, the optimum operating... 

    Synthesis of spherical silica/multiwall carbon nanotubes hybrid nanostructures and investigation of thermal conductivity of related nanofluids

    , Article Thermochimica Acta ; Volume 549 , 2012 , Pages 87-94 ; 00406031 (ISSN) Baghbanzadeh, M ; Rashidi, A ; Rashtchian, D ; Lotfi, R ; Amrollahi, A ; Sharif University of Technology
    In this study, a hybrid of silica nanosphere/multiwall carbon nanotube (MWCNT) has been synthesized by wet chemical method at room temperature. The effect of MWCNTs, silica nanospheres and hybrid nanostructures (80% silica nanosphere/20% MWCNT and 50% silica nanosphere/50% MWCNT) on the thermal conductivity of distilled water has been investigated. SDBS was used as the dispersant to stabilize nanomaterials in the aqueous suspension and its concentration was 1.5 times of the concentration of nanomaterials. As results show, by increasing the concentration of nanomaterials, effective thermal conductivity of nanofluids increased. The most and the least enhancement in the effective thermal... 

    Core-shell γ-Fe2O3/SiO2/PCA/Ag-NPs hybrid nanomaterials as a new candidate for future cancer therapy

    , Article International Journal of Nanoscience ; Vol. 13, issue. 1 , February , 2014 Soleyman, R ; Pourjavadi, A ; Masoud, N ; Varamesh, A ; Sharif University of Technology
    In the current study, γ-Fe2O3/SiO 2/PCA/Ag-NPs hybrid nanomaterials were successfully synthesized and characterized. At first, prepared γ-Fe2O3 core nanoparticles were modified by SiO2 layer. Then they were covered by poly citric acid (PCA) via melting esterification method as well. PCA shell acts as an effective linker, and provides vacancies for conveying drugs. Moreover, this shell as an effective capping agent directs synthesis of silver nanoparticles (Ag-NPs) via in situ photo-reduction of silver ions by sunlight-UV irradiation. This system has several benefits as a suitable cancer therapy nanomaterial. Magnetic nanoparticles (MNPs) can guide Ag-NPs and drugs to cancer cells and then... 

    Hybrid nanomaterials containing PAMAM, polyrotaxane and quantum dot blocks

    , Article Nano ; Volume 6, Issue 3 , June , 2011 , Pages 239-249 ; 17932920 (ISSN) Adeli, M ; Sarabi, R. S ; Sadeghi, E ; Sharif University of Technology
    Pseudopolyrotaxanes, Ps-PR, consisting of α-cyclodextrin rings, polyethylene glycol axes and end triazine groups were prepared and then were capped by amino-functionalized quantum dots, NH 2-QDs, to achieve polyrotaxanes. The amino-functionalized QDs stoppers of polyrotaxanes were used as core to synthesize polyamidoamine, PAMAM, dendrons divergently and hybrid nanomaterials were obtained. Synthesized hybrid nanomaterials were characterized by different spectroscopy, microscopy and thermal analysis methods. They were freely soluble in water and their aqueous solutions were stable at room temperature over several months. Due to their biocompatible backbone, high functionality and water... 

    Efficient electrocatalytic oxidation of water and glucose on dendritic-shaped multicomponent transition metals/spongy graphene composites

    , Article Electrochimica Acta ; Volume 386 , 2021 ; 00134686 (ISSN) Nourmohammadi Khiarak, B ; Mohammadi, R ; Mojaddami, M ; Rahmati, R ; Hemmati, A ; Simchi, A ; Sharif University of Technology
    Elsevier Ltd  2021
    To improve the efficiency of electrochemical processes for environmental remediation, we present a new type of hybrid nanomaterials based on leaf-like copper-based quaternary transition metals and spongy monolayer graphene. To demonstrate the functionality of the hybrid electrocatalyst, fast and competent electrooxidation of water and glucose is shown. The mechanism of improved catalysis is ascribed to the synergetic catalytic effect of quaternary Cu-Ni-Fe-Co alloy with dendritic morphology along with the highly conductive and spongy structure of the graphene monolayer. It is shown that water oxidation can be performed at a low overpotential of 315 mV to reach a current denisty of 100 mA... 

    Polyrotaxane capped quantum dots as new candidates for cancer diagnosis and therapy

    , Article Journal of Nanostructured Polymers and Nanocomposites ; Volume 7, Issue 1 , 2011 , Pages 18-31 ; 17904439 (ISSN) Sarabi, R. S ; Sadeghi, E ; Hosseinkhani, H ; Mahmoudi, M ; Kalantari, M ; Adeli, M ; Sharif University of Technology
    Molecular self-assembly of cadmium selenide quantum dots-end-capped polyrotaxane hybrid nanostructures (PRCdSe QDs) was led to a new type of core-shell hybrid nanomaterials consisting of cadmium selenide quantum dot (CdSe QDs) core and polyrotaxane shell (PR@QDs). Structure of PR@QDs was characterized using various techniques. It has been observed that the size of PR@QDs was between 20-25 nm in which diameter of core and thickness of shell were between 15-20 and 2-3 nm, respectively. Short-term in vitro cytotoxicity tests, using MTT (3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, were conducted on mouse tissue connective fibroblast adhesive cell line (L929) in order to... 

    Synthesis of new hybrid nanomaterials: Promising systems for cancer therapy

    , Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 6 , 2011 , Pages 806-817 ; 15499634 (ISSN) Adeli, M ; Kalantari, M ; Parsamanesh, M ; Sadeghi, E ; Mahmoudi, M ; Sharif University of Technology
    Polyrotaxanes consisting of cyclodextrin rings, polyethylene glycol axes and quantum dot (QD) stoppers were synthesized and characterized. The molecular self-assembly of polyrotaxanes led to spindlelike nano-objects whose shape, size and position were dominated by QD stoppers. Due to their well-defined molecular self-assemblies, carbohydrate backbone, high functionality and several types of functional groups together with the high luminescence yield, synthesized hybrid nanostructures were recognized as promising candidates for biomedical applications. The potential applications of the molecular self-assemblies as drug-delivery systems was investigated by conjugation of doxorubicin (DOX) to... 

    A possible anticancer drug delivery system based on carbon nanotube-dendrimer hybrid nanomaterials

    , Article Journal of Materials Chemistry ; Volume 21, Issue 39 , 2011 , Pages 15456-15463 ; 09599428 (ISSN) Mehdipoor, E ; Adeli, M ; Bavadi, M ; Sasanpour, P ; Rashidian, B ; Sharif University of Technology
    Iron oxide nanoparticles, γ-Fe2O3NP, were deposited onto the surface of multi-walled carbon nanotubes and CNT/γ-Fe2O3NP hybrid nanomaterials were obtained. Then linear-dendritic ABA type block copolymers consisting of polyethylene glycol as B block and poly(citric acid) as A block, PCA-PEG-PCA, were synthesized and cisplatin (cis-diamminedichloroplatinum (CDDP) - a platinum-based chemotherapy drug) was conjugated with their carboxyl functional groups and CDDP/PCA-PEG-PCA anticancer prodrugs were prepared. Noncovalent interactions between CDDP/PCA-PEG-PCA anticancer prodrugs and CNT/γ-Fe2O3NP hybrid nanomaterials led to CDDP/PCA-PEG-PCA/CNT/γ-Fe2O3NP drug delivery systems. There are several... 

    Design and Synthesis of Novel Polyglycerol Hybrid Nanomaterials for Potential Applications in Drug Delivery Systems

    , Article Macromolecular Bioscience ; Volume 11, Issue 3 , NOV , 2011 , Pages 383-390 ; 16165187 (ISSN) Zarrabi, A ; Adeli, M ; Vossoughi, M ; Shokrgozar, M. A ; Sharif University of Technology
    The synthesis of a new drug delivery system based on hybrid nanomaterials containing a β-CD core and hyperbranched PG is described. Conjugating PG branches onto β-CD not only increases its water solubility but also affects its host/guest properties deeply. It can form molecular inclusion complexes with small hydrophobic guest molecules such as ferrocene or FITC with reasonable release. In addition, the achievable payloads are significantly higher as for carriers such as hyperbranched PGs. Short-term in vitro cytotoxicity and hemocompatibility tests on L929 cell lines show that the hybrid nanomaterial is highly biocompatible. Due to their outstanding properties, β-CD-g-PG hybrid nanomaterials... 

    Synthesis of pseudopolyrotaxanes-coated superparamagnetic Iron oxide nanoparticles as new MRI contrast agent

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 103 , March , 2013 , Pages 652-657 ; 09277765 (ISSN) Hosseini, F ; Panahifar, A ; Adeli, M ; Amiri, H ; Lascialfari, A ; Orsini, F ; Doschak, M. R ; Mahmoudi, M ; Sharif University of Technology
    Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of α-cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher... 

    Synthesis and characterization of magnetic hybrid nanomaterials via RAFT polymerization: A pH sensitive drug delivery system

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 174 , 2019 , Pages 153-160 ; 09277765 (ISSN) Pourjavadi, A ; Kohestanian, M ; Shirzad, M ; Sharif University of Technology
    Elsevier B.V  2019
    Herein, a facile and versatile method for the synthesis of a novel magnetic nanocarrier via surface- initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is introduced. At first, RAFT agent was successfully attached to the surface of Fe 3 O 4 nanoparticles and, then, poly (glycidyl methacrylate) (PGMA) chains were grown and anchored onto the surface of Fe 3 O 4 nanoparticles. At the end, hydrazine (Hy) groups were introduced to the PGMA chains via reaction between epoxy rings and hydrazine molecules. Doxorubicin (DOX) was covalently conjugated to the prepared nanocarrier (Fe 3 O 4 @PGMA@Hy) through a hydrazone linkage. The in vitro drug release of Fe 3 O 4...