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hydroxyapatite-depositions
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Loading drug on nanostructured Ti6Al4V-HA for implant applications
, Article International Journal of Engineering, Transactions B: Applications ; Volume 31, Issue 8 , 2018 , Pages 1159-1165 ; 1728144X (ISSN) ; Sadrnezhaad, S. K ; Sharif University of Technology
Materials and Energy Research Center
2018
Abstract
Arrayed Ti6Al4V nanotubes (TNT) coated with hydroxyapatite (HA) were synthesized via electrochemical anodization method. Paracetamol was loaded onto TNT-HA electrode. Effects of anodization, nanotube formation and hydroxyapatite deposition on sorption and release of the drug were investigated. Saturation time of paracetamol on the anodized samples was 30% shorter than the hydroxyapatite-coated samples. Release behavior of the loaded drug was studied by (a) plunging the probe into phosphate buffered saline (PBS), (b) sampling the drug-loaded PBS at different times and (c) analyzing the solution via ultraviolet-visible (UV-vis) spectroscopy. Results showed that HA electrodes hold higher...