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Authors’ reply to a comment on M. pasdar et al article
, Article Colloids and Surfaces A: Physicochemical and Engineering Aspects ; Volume 561 , 2019 , Pages 407-408 ; 09277757 (ISSN) ; Kazemzadeh, E ; Kamari, E ; Ghazanfari, M. H ; Soleymani, M ; Sharif University of Technology
Elsevier B.V
2019
Mathematical Modeling and Simulation of Hyperbaric Oxygen Therapy in Tumor Growth Process
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaei, Mohammad Jafar (Supervisor) ; Saadatmand, Maryam (Co-Supervisor)
Abstract
Today cancer is one of the leading causes of death worldwide. It is caused by some cells that they gather together in part of the body and they have an abnormal and very high proliferation rate. Investigations on tumors have shown that when tumor volume increases, oxygen concentration in some regions of tumors decreases and this hypoxic condition leads to some cancer hallmarks, e.g. angiogenesis, deregulation of apoptosis, and shift in cell energy sources. So treatment strategies that can increase tissue oxygenation are good choices for cancers. Hyperbaric oxygen therapy (HBOT) which is used to treat diabetic ulcers and carbon monoxide poisoning, have been used experimentally for cancer and...
In Silico Lung-on-a-Chip Simulation for Disease Modeling and Drug Delivery Purposes
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Mashayekhan, Shohreh (Supervisor) ; Moghadas, Hajar (Co-Supervisor)
Abstract
Organ-on-chip microfluidic devices create a three-dimensional and dynamic model that allows researchers to model diseases and test different drug candidates. In this regard, using a lung-on-a-chip microfluidic device, Covid-19 disease was numerically modeled. Initially, the distribution of oxygen concentration in the blood and respiratory membrane in the healthy state; when the respiratory membrane is the only barrier between air and blood; was found and observed that in this case, the length that the blood had to travel to reach full saturation was the same in the alveolar capillaries and the lung-on-a-chip microdevice. Then, to simulate the different phases of the disease, the formation of...