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Modeling of photoplethysmography signal for quantitative analysis of endothelial cells during reactive hyperemia, Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 174-178 ; 9781467331302 (ISBN) ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
In this study, at first the cardiovascular system is modeled based on the 1D method and then the simulation of the reactive hyperemia experiment has been applied on the model. In this simulation, by applying a cuff at the brachial artery, the flow downstream of the cuff is occluded. Then with releasing the cuff immediately, a large amount of shear stress, about 4 times the basal amount, is applied downstream of the cuff and consequently to the endothelial cells in a very short moment. Considering a reported experimental transfer function between shear stress and vasodilation, the increase of the artery diameter due to the sudden increase of the shear stress is obtained. Finally, the...