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immunoglobulin-enhancer-binding-protein
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Assessment of expression of NF-κB-related genes in periodontitis
, Article Gene Reports ; Volume 26 , 2022 ; 24520144 (ISSN) ; Gholami, L ; Nazer, N ; Hussen, B. M ; Shadnoush, M ; Sayad, A ; Taheri, M ; Sharif University of Technology
Elsevier Inc
2022
Abstract
Nuclear factor kappa B (NF-κB) is an important regulator of immune responses and is involved in the pathoetiology of periodontitis. We have measured levels of four NF-κB-related genes, namely CEBPA, CEBPA-DT, FBXL19-AS and DILC in blood and tissue samples of patients with chronic periodontitis compared with controls. Expression of CEBPA-DT was significantly lower in blood of patients compared with controls (Ratio of mean expression (RME) = 0.13, P value = 0.01). This pattern was also seen among male subgroups (RME = 0.10, P value = 0.01). FBXL19-AS was down-regulated in venous blood of total patients compared with controls (RME = 0.03, P value < 0.001) and in patients of both sexes compared...
Optimized doxycycline-loaded niosomal formulation for treatment of infection-associated prostate cancer: An in-vitro investigation
, Article Journal of Drug Delivery Science and Technology ; Volume 57 , 2020 ; Tavakkoli Yaraki, M ; Bourbour, M ; Noorbazargan, H ; Lajevardi, A ; Sadat Shilsar, S. M ; Heidari, F ; Mousavian, S. M ; Sharif University of Technology
Editions de Sante
2020
Abstract
Developing drug delivery systems with both antibacterial and anti-cancer effects is of importance in the treatment process of infection-associated cancers, especially prostate cancer. In this study, Span 60, Tween 60, and cholesterol were used to formulate doxycycline-loaded niosomes as a promising drug carrier system as either antibacterial or anticancer formulation. The formulation process was optimized by multi-objective response surface methodology (RSM), and then characterized. The developed niosomal formulation showed great storage stability for up to 2 weeks. In addition, they showed remarkable drug release in acidic solution (pH = 3) compared with physiological pH (7.4). The in-vitro...
Abnormal expression of NF-κB-related transcripts in blood of patients with inflammatory peripheral nerve disorders
, Article Metabolic Brain Disease ; Volume 36, Issue 8 , 2021 , Pages 2369-2376 ; 08857490 (ISSN) ; Ghafouri Fard, S ; Badrlou, E ; Omrani, D ; Nazer, N ; Sayad, A ; Taheri, M ; Sharif University of Technology
Springer
2021
Abstract
The NF-κB family includes some transcription factors which have important functions in the regulation of immune responses, therefore participating in the pathophysiology of inflammatory conditions such as peripheral neuropathies. We have quantified expression of a number of NF-κB-related transcripts in patients with Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP) versus healthy subjects. These transcripts have been previously shown to be functionally related with this family of transcription factors. Expressions of ATG5, DICER-AS1, PACER, DILC, NKILA and ADINR have been increased in both CIDP and GBS patients compared with controls. However,...
Nonparametric simulation of signal transduction networks with semi-synchronized update
, Article PLoS ONE ; Volume 7, Issue 6 , 2012 ; 19326203 (ISSN) ; Masoudi Nejad, A ; Jalili, M ; Moeini, A ; Sharif University of Technology
2012
Abstract
Simulating signal transduction in cellular signaling networks provides predictions of network dynamics by quantifying the changes in concentration and activity-level of the individual proteins. Since numerical values of kinetic parameters might be difficult to obtain, it is imperative to develop non-parametric approaches that combine the connectivity of a network with the response of individual proteins to signals which travel through the network. The activity levels of signaling proteins computed through existing non-parametric modeling tools do not show significant correlations with the observed values in experimental results. In this work we developed a non-parametric computational...
Detection and a possible link between parvovirus B19 and thyroid cancer
, Article Tumor Biology ; Volume 39, Issue 6 , 2017 ; 10104283 (ISSN) ; Mostafaei, S ; Yari, K ; Ghasemi, A ; Chenar, H. M ; Moghoofei, M ; Sharif University of Technology
Abstract
Human parvovirus B19 (B19) is a small, non-enveloped virus and belongs to Parvoviridae family. B19 persists in many tissues such as thyroid tissue and even thyroid cancer. The main aim of this study was to determine the presence of B19, its association with increased inflammation in thyroid tissue, and thus its possible role in thyroid cancer progression. Studies have shown that virus replication in non-permissive tissue leads to overexpression of non-structural protein and results in upregulation of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha. A total of 36 paraffin-embedded thyroid specimens and serum were collected from patients and 12 samples were used...
Human papilloma virus and breast cancer: The role of inflammation and viral expressed proteins
, Article BMC Cancer ; Volume 19, Issue 1 , 2019 ; 14712407 (ISSN) ; Mostafaei, S ; Etemadi, A ; Ghasemi, A ; Payandeh, M ; Hadifar, S ; Norooznezhad, A. H ; Kazemnejad, A ; Moghoofei, M ; Sharif University of Technology
BioMed Central Ltd
2019
Abstract
Background: Breast cancer is currently the most common neoplasm diagnosed in women globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) infection may play a key role in invasiveness of breast cancer. The aim of this study was to determine the presence of HPV in patients with breast cancer and its possible association with cancer progression. Methods: Breast specimens were collected from 72 patients with breast cancer and 31 healthy controls. The presence of HPV was investigated by polymerase chain reaction (PCR) and genotyping was performed for positive cases. We also evaluated the viral factors such as E6, E2, and E7 in HPV positive cases. Enzyme-linked...
Seasonal variations in the oxidative stress and inflammatory potential of PM2.5 in Tehran using an alveolar macrophage model; The role of chemical composition and sources
, Article Environment International ; Volume 123 , 2019 , Pages 417-427 ; 01604120 (ISSN) ; Antkiewicz, D. S ; Hemming, J. D. C ; Shafer, M. M ; Lai, A. M ; Arhami, M ; Hosseini, V ; Schauer, J. J ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
The current study was designed to assess the association between temporal variations in urban PM2.5 chemical composition, sources, and the oxidative stress and inflammatory response in an alveolar macrophage (AM) model. A year-long sampling campaign collected PM2.5 samples at the Sharif University in Tehran, Iran. PM-induced reactive oxygen species (ROS) production was measured both with an acellular dithiothreitol consumption assay (DTT-ROS; ranged from 2.1 to 9.3 nmoles min−1 m−3) and an in vitro macrophage-mediated ROS production assay (AM-ROS; ranged from 125 to 1213 μg Zymosan equivalents m−3). The production of tumor necrosis factor alpha (TNF-α; ranged from ~60 to 518 pg TNF-α m−3)...