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immunopathology
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Distribution of HLA alleles and genotypes in patients with chronic inflammatory demyelinating polyneuropathy
, Article Journal of Molecular Neuroscience ; Volume 72, Issue 3 , 2022 , Pages 574-584 ; 08958696 (ISSN) ; Akbari, M. T ; Houlden, H ; Mazdeh, M ; Nazer, N ; Rezaei, O ; Taheri, M ; Sayad, A ; Sharif University of Technology
Humana Press Inc
2022
Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among cases compared with controls (OR [95% CI] = 4.82 [2.06, 11.3], P value =...