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Hybrid silk fibroin–gelatin nanofibrous sheet for drug delivery and regenerative medicine: In-vitro characterization and controlled release of simvastatin/protein
, Article Polymers for Advanced Technologies ; 2020 ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
John Wiley and Sons Ltd
2020
Abstract
Blend drug-loading method in electrospun scaffolds has gained much attention as a cost-effective and simple delivery system in regenerative medicine. However, it has some drawbacks, such as the burst release of encapsulated drugs and denaturing active agents in harsh organic solvents. In this study, a new silk fibroin-gelatin (SF–G) fibrous sheet has been introduced as an engineered scaffold and a straightforward drug delivery system for skin tissue engineering applications. The hybrid sheets have been prepared via co-electrospinning and in-situ crosslinking methods without corrosive solvents and toxic crosslinking agents. To evaluate the proposed scaffold as a controlled release system, the...