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    A meta-model analysis of a finite element simulation for defining poroelastic properties of intervertebral discs

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 227, Issue 6 , 2013 , Pages 672-682 ; 09544119 (ISSN) Nikkhoo, M ; Hsu, Y. C ; Haghpanahi, M ; Parnianpour, M ; Wang, J. L ; Sharif University of Technology
    2013
    Abstract
    Finite element analysis is an effective tool to evaluate the material properties of living tissue. For an interactive optimization procedure, the finite element analysis usually needs many simulations to reach a reasonable solution. The metamodel analysis of finite element simulation can be used to reduce the computation of a structure with complex geometry or a material with composite constitutive equations. The intervertebral disc is a complex, heterogeneous, and hydrated porous structure. A poroelastic finite element model can be used to observe the fluid transferring, pressure deviation, and other properties within the disc. Defining reasonable poroelastic material properties of the... 

    A regenerative approach towards recovering the mechanical properties of degenerated intervertebral discs: Genipin and platelet-rich plasma therapies

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 231, Issue 2 , 2017 , Pages 127-137 ; 09544119 (ISSN) Nikkhoo, M ; Wang, J. L ; Abdollahi, M ; Hsu, Y. C ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
    SAGE Publications Ltd  2017
    Abstract
    Degenerative disc disease, associated with discrete structural changes in the peripheral annulus and vertebral endplate, is one of the most common pathological triggers of acute and chronic low back pain, significantly depreciating an individual's quality of life and instigating huge socioeconomic costs. Novel emerging therapeutic techniques are hence of great interest to both research and clinical communities alike. Exogenous crosslinking, such as Genipin, and platelet-rich plasma therapies have been recently demonstrated encouraging results for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding the quantitative degree of effectiveness and...