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    Prevalence of influenza a infection in the middle-east: a systematic review and meta-analysis

    , Article Clinical Respiratory Journal ; Volume 12, Issue 5 , 2018 , Pages 1787-1801 ; 17526981 (ISSN) Moghoofei, M ; Monavari, H. R ; Mostafaei, S ; Hadifar, S ; Ghasemi, A ; Babaei, F ; Kavosi, H ; Tavakoli, A ; Javanmard, D ; Esghaei, M ; Khodabandehlou, N ; Sharif University of Technology
    Blackwell Publishing Ltd  2018
    Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were ‘Influenza’, ‘Subtype’, ‘Seroprevalence’, ‘Incidence’, ‘Seroepidemiology’, ‘H1N1’, ‘H3N2’, ‘H5N1’, ‘H9N2’, ‘Middle-East’ and ‘Meta-analysis’. The reported data were selected according to inclusion and exclusion criteria. Results: The authors selected 71 studies out of... 

    Inactivation methods for whole influenza vaccine production

    , Article Reviews in Medical Virology ; Volume 29, Issue 6 , 2019 ; 10529276 (ISSN) Sabbaghi, A ; Miri, S. M ; Keshavarz, M ; Zargar, M ; Ghaemi, A ; Sharif University of Technology]
    John Wiley and Sons Ltd  2019
    Despite tremendous efforts toward vaccination, influenza remains an ongoing global threat. The induction of strain-specific neutralizing antibody responses is a common phenomenon during vaccination with the current inactivated influenza vaccines, so the protective effect of these vaccines is mostly strain-specific. There is an essential need for the development of next-generation vaccines, with a broad range of immunogenicity against antigenically drifted or shifted influenza viruses. Here, we evaluate the potential of whole inactivated vaccines, based on chemical and physical methods, as well as new approaches to generate cross-protective immune responses. We also consider the mechanisms by... 

    Evaluating the Effect of Antiviral Agents on Influenza H1N1 Virus

    , M.Sc. Thesis Sharif University of Technology Haghayegh Khorasani, Sara (Author) ; Roosta Azad, Reza (Supervisor) ; Dorostkar, Ruhollah (Supervisor)
    With the epidemic of viral diseases in humans and animals, and their potential to cause irreparable economic damages, due to their recent noticeable changes in their structures followed by becoming antibiotic resistance, many researchers nowadays are focusing on the new antiviral Agents with least side effects. Influenza A virus is a common seasonal virus which can lead to sever infections. This type of influenza has the ability to transmit between humans and animals, and also by antigenic shifts can transform to new type of influenza which can cause a global disaster. While classical antiviral drugs are still in use for influenza patients, new influenza A subtypes become resistant to these... 

    Proposing a Control Method for Influenza Disease

    , M.Sc. Thesis Sharif University of Technology Mahmoodi, Marjan (Author) ; Shahrokhi, Mohammad (Supervisor)
    Immediate control of pandemic influenza to avoid casualties and financial losses is an important issue. In this thesis, two types of controllers including optimal controller and adaptive generalized predictive controller based on linear input-output model, with vaccine, treatment and quarantine being controlling variables, have been used to control influenza. Each controlling methods were investigated for different states including single-input single-output and multi-input single-output. Single-input single-output and multi-input single-output models are identified as online and offline using least squares method. Since it is difficult to exactly identify the model parameters, especially at... 

    Optimal Two-Phase Vaccine Allocation under Uncertain Impacts and Different Transition Rates

    , M.Sc. Thesis Sharif University of Technology Dodangeh, Sana (Author) ; Najafi, Mehdi (Supervisor) ; Rafiee, Majid (Supervisor)
    Infectious diseases have always threatened the health of human beings. One of the most important causes of mortality in human societies is infectious diseases. The spread of these diseases in society, even if does not lead to death, can have devastating effects on society. Influenza is one of the infectious diseases that has attracted much attention today. It can be mild or severe and even cause hospitalization and death. Therefore, controlling and preventing the epidemic of this disease is very important. Epidemic models are commonly used to simulate the spread of infectious diseases. In this study to identify the influenza outbreak, a stochastic multigroup SEIR model with the migration... 

    The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?

    , Article Microbial Pathogenesis ; Volume 148 , November , 2020 Mahooti, M ; Miri, S. M ; Abdolalipour, E ; Ghaemi, A ; Sharif University of Technology
    Academic Press  2020
    Respiratory virus infections are among the most prevalent diseases in humans and contribute to morbidity and mortality in all age groups. Moreover, since they can evolve fast and cross the species barrier, some of these viruses, such as influenza A and coronaviruses, have sometimes caused epidemics or pandemics and were associated with more serious clinical diseases and even mortality. The recently identified Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International concern and has been associated with rapidly progressive pneumonia. To ensure protection against emerging respiratory tract... 

    Synergy between hemagglutinin 2 (HA2) subunit of influenza fusogenic membrane glycoprotein and oncolytic Newcastle disease virus suppressed tumor growth and further enhanced by Immune checkpoint PD-1 blockade

    , Article Cancer Cell International ; Volume 20, Issue 1 , August , 2020 Miri, S. M ; Ebrahimzadeh, M. S ; Abdolalipour, E ; Yazdi, M ; Hosseini Ravandi, H ; Ghaemi, A ; Sharif University of Technology
    BioMed Central Ltd  2020
    Background: Newcastle disease virus (NDV) has shown noticeable oncolytic properties, especially against cervical cancer. However, in order to improve the spread rate and oncotoxicity of the virus, employment of other therapeutic reagents would be helpful. It has been shown that some viral fusogenic membrane glycoproteins (FMGs) could facilitate viral propagation and increase the infection rate of tumor cells by oncolytic viruses. Additionally, immune checkpoint blockade has widely been investigated for its anti-tumor effects against several types of cancers. Here, we investigated for the first time whether the incorporation of influenza hemagglutinin-2 (HA2) FMG could improve the oncolytic... 

    Nonlinear robust adaptive sliding mode control of influenza epidemic in the presence of uncertainty

    , Article Journal of Process Control ; Volume 56 , 2017 , Pages 48-57 ; 09591524 (ISSN) Sharifi, M ; Moradi, H ; Sharif University of Technology
    Elsevier Ltd  2017
    In this paper, a nonlinear robust adaptive sliding mode control strategy is presented for the influenza epidemics in the presence of model uncertainties. The nonlinear epidemiological model of influenza with five state variables (the numbers of susceptible, exposed, infected, asymptomatic and recovered individuals) and two control inputs (vaccination and antiviral treatment) is considered. The objective of the proposed controller is decreasing the number of susceptible and infected humans to zero by tracking the desired scenarios. As a result of this decreasing, the number of exposed and asymptomatic individuals is also decreased and converged to the zero. Accordingly, it is shown that the... 

    Design of an effective piezoelectric microcantilever biosensor for rapid detection of COVID-19

    , Article Journal of Medical Engineering and Technology ; Volume 45, Issue 6 , 2021 , Pages 423-433 ; 03091902 (ISSN) Kabir, H ; Merati, M ; Abdekhodaie, M. J ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19, is one of the most contagious viruses resulting in a progressive pandemic. Since specific antiviral treatments have not been developed yet and its fatal rate is almost high, early and fast detection is critical for controlling the outbreak. In this study, a piezoelectric microcantilever biosensor has been designed for detecting COVID-19 samples directly without requiring preparation steps. The biosensor acts as a transducer and is coated with the related antibody. When the SARS-CoV-2 antigens adsorbed on the microcantilever top surface through their spike proteins, a surface stress due to the mass change would be...