Sharif Digital Repository

Combined composites consisting of nanofibers and hydrogels were fabricated to grow cells in an environment that mimicked the extracellular matrix. Electrospan nanofibers were spun and hydrolyzed under optimized conditions consisting of polycaprolactone (PCL) and gelatin and then incorporated into alginate and gelatin hydrogels. Nanofibril-containing (NF / hydrogel) hydrogel hybrids were ligated by calcium chloride in the presence of encapsulated beta cells. The mechanical properties of NF / hydrogel scaffolds were significantly increased in proportion to the NF content in NF / hydrogels. Beta cells killed in NF / hydrogels showed higher adhesion to the matrix compared to samples without NF.... 

Diabete is disability in the body to produce insulin or use it. Body insulin hormone needed to convert starch, sugar and other foods to energy and thus the body is functioning properly. Considering this incurable disease and its complications, many doctors and researchers trying to control the disease, reduce complications and to create favorable conditions and appropriate solutions for preventing its expanding and also strengthening patients mentally. Be destroyed in digestive system, insulin can not through tablets or similar cases received. The best way known to enter insulin to the body, is injection. This project is about a device to reduce the level of blood glucose in patients with... 

Proteins carry out most important roles in the organisms and they have a number of functions including structural, catalytically, regulatory and transportal, However for protein to have functional role they must be able to possess tridimensional structure. Several proteins due to various genetic and physico-chemical conditions have shown to alter their tridimensional structure leading to insoluble fibrilar structure. One of the properties of these insoluble fibrils is conformational change, converting to β-sheet rich structures; the entire process of converting soluble to proteins insoluble fibrils known as amyloid formation. The proteins amyloidosis have been seen as causative role in a... 

Diabetes is a global problem as a silent epidemic disorder. Diabetes Mellitus has involved at least five percent of our population. It will cause so many complications and end-organs effects if it is not controlled. Today, treatment and control of diseases using computational intelligent systems has been paid a lot of attention to. That’s why this study has taken treatment and control of diabetes into consideration. So, the neural networks have been used to manage and treat diabetes. To do this, real data from diabetic patients has been gathered and based on the data, a model has been obtained to show the effect of insulin on the amount of blood glucose. Then, a neural network controller has... 

Continous blood glucose control has great importance for type 1 dyabetic patients. In this thesis, several types of controllers including: PI controller, model predictive controller base on state space model, linear model predictive controller base of linear input-output model and non-linear model predictive controller base of Hammerstein model have been used to regulate blood glucose of patients with type 1 diabetes. These models are identified using least squars method. Performance of these controllers is tested and the best one is introduced. For rejecting meal disturbances, a feedforward controller has been designed. Combination of feedback and feedforward controller would properly... 

Type 1 diabetes, formerly known as insulin-dependent diabetes, may present at any age, but is the most common type of diabetes affecting children and adolescents. People with type 1 diabetes do not produce enough insulin. This type accounts for 5-10% of all types of diabetes. In this type of diabetes, beta cell destruction occurs in the pancreas. In type 1 diabetes, the pancreas does not secrete any insulin; insulin is a hormone that enables the body to convert glucose in food into energy. If sugar in the blood cannot enter the cells, it accumulates in the arteries and results in high blood sugar. High blood sugar over time can have irreversible effects on various parts of the body. Curcumin... 

Insulin pump treatment is considered the most physiological way to imitate the healthy body's insulin profile in patients with diabetes. They provide a precisely controlled rate of insulin delivery to diabetic patients who would normally need multiple daily injections to regulate blood glucose levels. The firmware allows numerous modifications to the bolus dose and basal rate to enable patients to manage insulin levels in response to events such as eating, sleeping, and exercise.
In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a... 

Beta cells are responsible for secreting insulin to maintain normoglycaemia throughout the individual’s life. Type 1 Diabetes Mellitus (T1DM) is a metabolic disorder characterized by an autoimmune response that promotes the destruction of beta-cells within the pancreatic islets, resulting in lifelong inadequate insulin secretion. Encapsulating beta cells inside a semipermeable membrane to protect encapsulated cells from direct contact with the host immune system, is a new way to treat type 1 diabetes without the need for long-term immunosuppression. . In this case, the semipermeable membrane surrounds the cells and allows oxygen, nutrients, and cell products to penetrate bilaterally while...