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Nanobiomaterials set to revolutionize drug-delivery systems for the treatment of diabetes: State-of-the-art
, Article Nanobiomaterials in Drug Delivery: Applications of Nanobiomaterials ; 2016 , Pages 487-514 ; 9780323428897 (ISBN) ; Rezvani, Z ; Ramedani, A ; Gholipourmalekabadi, M ; Chauhan, N. P. S ; Moztarzadeh, S ; Urbanska, A ; Mozafari, M ; Sharif University of Technology
Elsevier Inc
2016
Abstract
Diabetes can result when the accurate control of insulin levels fails in the body. As a result, insulin has been conventionally administered for the treatment of diabetes mainly through subcutaneous injection. There have been several attempts to administer insulin orally. However, the oral bioavailability of insulin is strictly limited, mainly by low permeability across biological membranes. Advances in biotechnology and nanotechnology have recently led to the discovery of several new approaches for the delivery of drugs. In this concept, nanobiomaterials have been shown to be promising candidates for oral insulin delivery. This chapter describes the recent advances and future prospects of...
A perspective to the correlation between brain insulin resistance and alzheimer: medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
A perspective to the correlation between brain insulin resistance and Alzheimer: Medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
Optimization of Insulin Release from Beta Cells Using Hybrid Scaffold Bioengineering
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
Abstract
Combined composites consisting of nanofibers and hydrogels were fabricated to grow cells in an environment that mimicked the extracellular matrix. Electrospan nanofibers were spun and hydrolyzed under optimized conditions consisting of polycaprolactone (PCL) and gelatin and then incorporated into alginate and gelatin hydrogels. Nanofibril-containing (NF / hydrogel) hydrogel hybrids were ligated by calcium chloride in the presence of encapsulated beta cells. The mechanical properties of NF / hydrogel scaffolds were significantly increased in proportion to the NF content in NF / hydrogels. Beta cells killed in NF / hydrogels showed higher adhesion to the matrix compared to samples without NF....
Subcutaneous insulin administration by deep reinforcement learning for blood glucose level control of type-2 diabetic patients
, Article Computers in Biology and Medicine ; Volume 148 , 2022 ; 00104825 (ISSN) ; Niazmand, V. R ; Eqra, N ; Vatankhah, R ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Background: Type-2 diabetes mellitus is characterized by insulin resistance and impaired insulin secretion in the human body. Many endeavors have been made in terms of controlling and reducing blood glucose via the medium of automated controlling tools to increase precision and efficiency and reduce human error. Recently, reinforcement learning algorithms are proved to be powerful in the field of intelligent control, which was the motivation for the current study. Methods: For the first time, a reinforcement algorithm called normalized advantage function (NAF) algorithm has been applied as a model-free reinforcement learning method to regulate the blood glucose level of type-2 diabetic...
Insulin Pen Design With Pahl & Beitz Approach and Prototyping
, M.Sc. Thesis Sharif University of Technology ; Saadat Foumani, Mahmoud (Supervisor)
Abstract
Diabete is disability in the body to produce insulin or use it. Body insulin hormone needed to convert starch, sugar and other foods to energy and thus the body is functioning properly. Considering this incurable disease and its complications, many doctors and researchers trying to control the disease, reduce complications and to create favorable conditions and appropriate solutions for preventing its expanding and also strengthening patients mentally. Be destroyed in digestive system, insulin can not through tablets or similar cases received. The best way known to enter insulin to the body, is injection. This project is about a device to reduce the level of blood glucose in patients with...
Controlling Amyloid Formation Using Novel Carbon Based Nanoparticles
, M.Sc. Thesis Sharif University of Technology ; Kalhor, Hamid Reza (Supervisor)
Abstract
Proteins carry out most important roles in the organisms and they have a number of functions including structural, catalytically, regulatory and transportal, However for protein to have functional role they must be able to possess tridimensional structure. Several proteins due to various genetic and physico-chemical conditions have shown to alter their tridimensional structure leading to insoluble fibrilar structure. One of the properties of these insoluble fibrils is conformational change, converting to β-sheet rich structures; the entire process of converting soluble to proteins insoluble fibrils known as amyloid formation. The proteins amyloidosis have been seen as causative role in a...
Management and Treatment of Diabetes Artificial Neural Networks Controllers
, M.Sc. Thesis Sharif University of Technology ; Seifipour, Navid (Supervisor)
Abstract
Diabetes is a global problem as a silent epidemic disorder. Diabetes Mellitus has involved at least five percent of our population. It will cause so many complications and end-organs effects if it is not controlled. Today, treatment and control of diseases using computational intelligent systems has been paid a lot of attention to. That’s why this study has taken treatment and control of diabetes into consideration. So, the neural networks have been used to manage and treat diabetes. To do this, real data from diabetic patients has been gathered and based on the data, a model has been obtained to show the effect of insulin on the amount of blood glucose. Then, a neural network controller has...
Optimizing fuzzy logic controller for diabetes type I by genetic algorithm
, Article 2010 The 2nd International Conference on Computer and Automation Engineering, ICCAE 2010, 26 February 2010 through 28 February 2010, Singapore ; Volume 2 , 2010 , Pages 4-8 ; 9781424455850 (ISBN) ; Azizi, A ; Sharif University of Technology
2010
Abstract
Biological systems are highly nonlinear, and there is a significant amount of variability from one patient to another. A controller for drug infusion has to be able to achieve good performance for most of the potential patient population. These controllers are designed for the general population, as no knowledge is available before hand for each particular patient. This necessitates perforce an algorithm that will be able to compensate for the differences between individuals and external factors. Of the possibilities, fuzzy logic direct model reference adaptive control (DMRAC) is the choice for Insulin infusion control for diabetes type I as results presented herein. Safety and robustness...
Modeling of a glucose sensitive composite membrane for closed-loop insulin delivery
, Article Journal of Membrane Science ; Volume 335, Issue 1-2 , 2009 , Pages 21-31 ; 03767388 (ISSN) ; Wu, X. Y ; Sharif University of Technology
2009
Abstract
A theoretical model was developed to describe a dynamic process involving an enzymatic reaction and diffusion of reactants and product inside glucose sensitive composite membrane. The composite membrane consisted of nanoparticles of a weakly acidic polymer, glucose oxidase and catalase embedded in a hydrophobic polymer. Time- and position-dependent diffusivity of involved species was considered in the model. Donnan equilibrium was used to find concentrations of buffer ions inside the membrane. The profiles of pH, species concentrations, volume fraction of swollen gel, polymer and water-filled space, as well as solute diffusivity inside the membrane were predicted by the model as a function...
Involvement of TGF-β and autophagy pathways in pathogenesis of diabetes: a comprehensive review on biological and pharmacological insights
, Article Frontiers in Pharmacology ; Volume 11 , 15 September , 2020 ; Sajadimajd, S ; Mirzarazi, E ; Haratipour, P ; Joshi, T ; Farzaei, M. H ; Khan, H ; Echeverria, J ; Sharif University of Technology
Frontiers Media S.A
2020
Abstract
Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechanisms of diabetes still need to be explored. This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-β signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated...
Amyloid fibril reduction through covalently modified lysine in HEWL and insulin
, Article Archives of Biochemistry and Biophysics ; Volume 727 , 2022 ; 00039861 (ISSN) ; Kalhor, H. R ; Sharif University of Technology
Academic Press Inc
2022
Abstract
Proteins possess a variety of nucleophiles, which can carry out different reactions in the functioning cells. Proteins endogenously and synthetically can be modified through their nucleophilic sites. The roles of these chemical modifications have not been completely revealed. These modifications can alter the protein folding process. Protein folding directly affects the function of proteins. If an error in protein folding occurs, it may cause protein malfunction leading to several neurodegenerative disorders such as Alzheimer's and Parkinson's. In this study, Hen Egg White Lysozyme (HEWL) and bovine insulin, as model proteins for studying the amyloid formation, were covalently attached with...
Blood Glucose Control in Human Body Using Model-Based Controllers
,
M.Sc. Thesis
Sharif University of Technology
;
Shahrokhi, Mohammad
(Supervisor)
Abstract
Continous blood glucose control has great importance for type 1 dyabetic patients. In this thesis, several types of controllers including: PI controller, model predictive controller base on state space model, linear model predictive controller base of linear input-output model and non-linear model predictive controller base of Hammerstein model have been used to regulate blood glucose of patients with type 1 diabetes. These models are identified using least squars method. Performance of these controllers is tested and the best one is introduced. For rejecting meal disturbances, a feedforward controller has been designed. Combination of feedback and feedforward controller would properly...
Investigation on Insulin Release from Microcapsules Containing Beta Cell
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
Abstract
Type 1 diabetes, formerly known as insulin-dependent diabetes, may present at any age, but is the most common type of diabetes affecting children and adolescents. People with type 1 diabetes do not produce enough insulin. This type accounts for 5-10% of all types of diabetes. In this type of diabetes, beta cell destruction occurs in the pancreas. In type 1 diabetes, the pancreas does not secrete any insulin; insulin is a hormone that enables the body to convert glucose in food into energy. If sugar in the blood cannot enter the cells, it accumulates in the arteries and results in high blood sugar. High blood sugar over time can have irreversible effects on various parts of the body. Curcumin...
The effect of a training program on body composition, growth hormone, insulin and insulin-like growth factor 1 in overweight female college students
, Article Gazzetta Medica Italiana Archivio per le Scienze Mediche ; Volume 171, Issue 4 , 2012 , Pages 409-416 ; 03933660 (ISSN) ; Tabrizi, A ; Sharif University of Technology
Abstract
Aim. The aim of this study was to determine the effect of a training program on body composition, GH, IGF-1 and insulin in overweight and obese female college students. Methods. The 17 overweight college student females divided into 2 groups: Experimental group (E) with 3 sessions per week, 6 weeks duration (N=9,Age=18.9 ± 1.3,BMI= 28.8 ± 2.6), and non-exercising control group (C) (N=8, Age=19.3 ± 1.8, BMI=26.3 ± 0.9). All measures included Vo2max, body composition, IGF-1, GH and insulin were done at baseline and following the protocol. Results. The calorie intake increased in both groups when compared to the baseline. The Vo2max increased statistically significant in E, and decreased in C....
Delay-Independent regulation of blood glucose for type-1 diabetes mellitus patients via an observer-based predictor feedback approach by considering quantization constraints
, Article European Journal of Control ; Volume 63 , January , 2021 , Pages 240-252 ; 09473580 (ISSN) ; Tavazoei, M. S ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Diabetes, as a widespread chronic disease, is caused by the increase of blood glucose concentration (BGC) due to pancreatic insulin production failure and/or insulin resistance in the body. The artificial pancreas (AP) known as a closed-loop insulin delivery control system consists of a glucose sensor for BGC measurement, a control algorithm for calculation of exogenous insulin delivery rate (IDR), and an insulin infusion pump. The AP provides a closed-loop glucose-insulin regulatory system for type-1 diabetes mellitus (T1DM) patients in order to effectively reduce the high BGC level. In this paper, we aim to design a controller in order to regulate the BGC of T1DM patients at its basal...
Delay-Independent regulation of blood glucose for type-1 diabetes mellitus patients via an observer-based predictor feedback approach by considering quantization constraints
, Article European Journal of Control ; Volume 63 , 2022 , Pages 240-252 ; 09473580 (ISSN) ; Tavazoei, M. S ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Diabetes, as a widespread chronic disease, is caused by the increase of blood glucose concentration (BGC) due to pancreatic insulin production failure and/or insulin resistance in the body. The artificial pancreas (AP) known as a closed-loop insulin delivery control system consists of a glucose sensor for BGC measurement, a control algorithm for calculation of exogenous insulin delivery rate (IDR), and an insulin infusion pump. The AP provides a closed-loop glucose-insulin regulatory system for type-1 diabetes mellitus (T1DM) patients in order to effectively reduce the high BGC level. In this paper, we aim to design a controller in order to regulate the BGC of T1DM patients at its basal...
Association of glomerular and tubular dysfunction with glycaemic control, lipid, lipoprotein, apolipoprotein and antioxidant status in type 2 diabetes mellitus
, Article Singapore Medical Journal ; Volume 48, Issue 9 , 2007 , Pages 840-846 ; 00375675 (ISSN) ; Djalali, M ; Siassi, F ; Farvid, S. S ; Sharif University of Technology
Singapore Medical Association
2007
Abstract
Introduction: This study was conducted to investigate the relationship of glomerular and tubular dysfunctions with glycaemic control, lipid, lipoprotein, apolipoproteins and antioxidant status in 72 patients with type 2 diabetes mellitus. Methods: Urine albumin concentration was measured by immunoturbidimetric and urine N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) activities with colorimetric methods. Glycated haemoglobin was measured using affinity chromatography. Erythrocyte glu ta thione reductase and glutathione peroxidase activities and serum levels of malondialdehyde, lipids, lipoproteins and apolipoproteins were determined in patients with type 2 diabetes...
Modeling, Simulation and Characterization of Pressurized Reservoir Insulin Pump
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Sani, Mahdi (Supervisor)
Abstract
Insulin pump treatment is considered the most physiological way to imitate the healthy body's insulin profile in patients with diabetes. They provide a precisely controlled rate of insulin delivery to diabetic patients who would normally need multiple daily injections to regulate blood glucose levels. The firmware allows numerous modifications to the bolus dose and basal rate to enable patients to manage insulin levels in response to events such as eating, sleeping, and exercise.
In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a...
In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a...
Optimization of Insulin Releasing from Hydrogel Encapsulated Beta Cells
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Co-Supervisor)
Abstract
Beta cells are responsible for secreting insulin to maintain normoglycaemia throughout the individual’s life. Type 1 Diabetes Mellitus (T1DM) is a metabolic disorder characterized by an autoimmune response that promotes the destruction of beta-cells within the pancreatic islets, resulting in lifelong inadequate insulin secretion. Encapsulating beta cells inside a semipermeable membrane to protect encapsulated cells from direct contact with the host immune system, is a new way to treat type 1 diabetes without the need for long-term immunosuppression. . In this case, the semipermeable membrane surrounds the cells and allows oxygen, nutrients, and cell products to penetrate bilaterally while...