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    Modeling, Simulation and Characterization of Pressurized Reservoir Insulin Pump

    , M.Sc. Thesis Sharif University of Technology Alipour, Davoud (Author) ; Saidi, Mohammad Said (Supervisor) ; Sani, Mahdi (Supervisor)
    Abstract
    Insulin pump treatment is considered the most physiological way to imitate the healthy body's insulin profile in patients with diabetes. They provide a precisely controlled rate of insulin delivery to diabetic patients who would normally need multiple daily injections to regulate blood glucose levels. The firmware allows numerous modifications to the bolus dose and basal rate to enable patients to manage insulin levels in response to events such as eating, sleeping, and exercise.
    In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a... 

    Delay-Independent regulation of blood glucose for type-1 diabetes mellitus patients via an observer-based predictor feedback approach by considering quantization constraints

    , Article European Journal of Control ; Volume 63 , January , 2021 , Pages 240-252 ; 09473580 (ISSN) Golestani, F ; Tavazoei, M. S ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Diabetes, as a widespread chronic disease, is caused by the increase of blood glucose concentration (BGC) due to pancreatic insulin production failure and/or insulin resistance in the body. The artificial pancreas (AP) known as a closed-loop insulin delivery control system consists of a glucose sensor for BGC measurement, a control algorithm for calculation of exogenous insulin delivery rate (IDR), and an insulin infusion pump. The AP provides a closed-loop glucose-insulin regulatory system for type-1 diabetes mellitus (T1DM) patients in order to effectively reduce the high BGC level. In this paper, we aim to design a controller in order to regulate the BGC of T1DM patients at its basal... 

    Delay-Independent regulation of blood glucose for type-1 diabetes mellitus patients via an observer-based predictor feedback approach by considering quantization constraints

    , Article European Journal of Control ; Volume 63 , 2022 , Pages 240-252 ; 09473580 (ISSN) Golestani, F ; Tavazoei, M. S ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Diabetes, as a widespread chronic disease, is caused by the increase of blood glucose concentration (BGC) due to pancreatic insulin production failure and/or insulin resistance in the body. The artificial pancreas (AP) known as a closed-loop insulin delivery control system consists of a glucose sensor for BGC measurement, a control algorithm for calculation of exogenous insulin delivery rate (IDR), and an insulin infusion pump. The AP provides a closed-loop glucose-insulin regulatory system for type-1 diabetes mellitus (T1DM) patients in order to effectively reduce the high BGC level. In this paper, we aim to design a controller in order to regulate the BGC of T1DM patients at its basal...