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A perspective to the correlation between brain insulin resistance and alzheimer: medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
A perspective to the correlation between brain insulin resistance and Alzheimer: Medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications
, Article Journal of Cellular Physiology ; Volume 234, Issue 10 , 2019 , Pages 17212-17231 ; 00219541 (ISSN) ; Singh, A. K ; Haratipour, P ; Sah, A. N ; Pandey, A. K ; Naseri, R ; Juyal, V ; Farzaei, M. H ; Sharif University of Technology
Wiley-Liss Inc
2019
Abstract
Diabetes affects a large population of the world. Lifestyle, obesity, dietary habits, and genetic factors contribute to this metabolic disease. A target pathway to control diabetes is the 5′-adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. AMPK is a heterotrimeric protein with α, β, and γ subunits. In several studies, AMPK activation enhanced glucose uptake into cells and inhibited intracellular glucose production. Impairment of AMPK activity is present in diabetes, according to some studies. Drugs used in the treatment of diabetes, such as metformin, are also known to act through regulation of AMPK. Thus, drugs that activate and regulate AMPK are potential...