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integrin-receptors
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Nontoxic concentrations of PEGylated graphene nanoribbons for selective cancer cell imaging and photothermal therapy
, Article Journal of Materials Chemistry ; Volume 22, Issue 38 , 2012 , Pages 20626-20633 ; 09599428 (ISSN) ; Ghaderi, E ; Emamy, H ; Sharif University of Technology
2012
Abstract
Reduced graphene oxide nanoribbons functionalized by amphiphilic polyethylene glycol (rGONR-PEG) were applied to attach arginine-glycine-aspartic acid (RGD)-based peptide and cyanine dye 3 (cy3) for targeting ανβ3 integrin receptors on human glioblastoma cell line U87MG and its selective fluorescence imaging, respectively. The rGONR-PEG suspension with a concentration of 100 μg mL -1 showed ∼14 and 2.4-fold higher near infrared (NIR) absorption at 808 nm than GONR (with dimensions of ∼80 nm × 1 μm) and rGO-PEG sheets (with lateral dimensions of ∼2 μm), respectively. The rGONR-PEG-cy3-RGD exhibited highly efficient NIR photothermal therapy performance (concentrations ≥1.0 μg mL-1 resulted in...