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interleukin-8
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Expression analysis of cytokine transcripts in inflammatory demyelinating polyradiculoneuropathy
, Article Metabolic Brain Disease ; Volume 36, Issue 7 , 2021 , Pages 2111-2118 ; 08857490 (ISSN) ; Ghafouri Fard, S ; Omrani, M. D ; Nazer, N ; Sayad, A ; Taheri, M ; Sharif University of Technology
Springer
2021
Abstract
Inflammatory demyelinating polyradiculoneuropathies are a group of peripheral nerve system disorders in which immune reactions are dysregulated. Cytokines have noticeable roles in the regulation of these responses. We compared transcript levels of nine cytokine coding genes namely IL-1B, IL-2, IL-4, IL-6, IL-8, IL-17A, IFN-G, TGF-B and TNF-A in the peripheral blood of patients with acute and chronic kinds of this condition (AIDP and CIDP) and healthy persons. Expression of IL-17A was significantly lower in female AIDP cases compared with female controls (Expression Ratio = 0.02, P value = 0.02). Expression of this cytokine was higher in female CIDP cases compared with female AIDP cases...