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interstitial-fluid
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Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement
, Article Biotechnology Reports ; Volume 34 , 2022 ; 2215017X (ISSN) ; Saidi, M. S ; Kazemzadeh Hannani, S ; Sharif University of Technology
Elsevier B.V
2022
Abstract
The aim of this paper is to design and numerically simulate the mass-transfer compartment and piezoelectric micropump of an implantable integrated microfluidic device for regular microdialysis-based nonenzymatic measurement of glucose level in diabetic patients. The device function is based on the process that the piezoelectric micropump pumps the dialysis fluid into the mass-transfer compartment microchannels, where the interstitial fluid (ISF) glucose diffusion into this dialysis fluid gives it a glucose content, then detected and measured in the sensor section. This diffusion takes place through the semipermeable membranes located in the microchannels at the base of the hollow...
Numerical simulation of a microfluidic system for regular glucose measurement
, Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 60-65 ; 9781728156637 (ISBN) ; Saidi, M. S ; Shahrokhian, S ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2019
Abstract
The aim of this research is to design an implantable integrated microfluidic system in order to regularly measure the glucose level in the human body, nonenzymatically, using the microdialysis method. The main compartments of this system are a micropump, array of hollow microneedles and an electrochemical sensor. At the base of the microneedles, there are located semipermeable membranes, that when the pumped dialysis fluid passes over them, the glucose of the interstitial fluid diffuses into the dialysis fluid and then, in the sensor section, it is measured nonenzymatically using the amperometry method. Both the arrangement of the miconeedles and the amount of the dialysis fluid flow are...
Design of a Microfluidic System for Continuous Glucose Measurement, as well as Fabricating and Experimentally Testing the Biosensor
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Kazemzadeh Hannani, Siamak (Supervisor) ; Shahrokhian, Saeed (Co-Supervisor)
Abstract
Diabetic patients, unlike other people whose blood glucose vary in a limited and normal range, encounter hyperglycemia and hypoglycemia, so their glucose level should be measured periodically and kept in the normal range. The aim of this research is to design an implantable integrated microfluidic system in order to regularly measure the glucose level in the human body, using the microdialysis method. The main compartments of this system are a micropump, array of hollow microneedles at the base of them located semipermeable membranes, the channels of dialysis fluid and an electrochemical sensor for measuring the glucose level. The micropump of this system is designed and simulated based on...
Multi-scale Simulation of Tumor Microenvironment
, M.Sc. Thesis Sharif University of Technology ; Firoozabadi, Bahar (Supervisor) ; Mozafari, Ali Asghar (Co-Supervisor)
Abstract
Search for effective methods for treating cancer requires a deep understanding of the tumor microenvironment and its role in cancerous tumor growth and progression. Mathematical modeling methods, which have fewer limitations than experimental methods for examining the microcirculation of cancer in detail, are suggested to answer many questions about the behavior and dynamics of cancerous tumors. In the present study, a multi-scale mathematical model of the three-dimensional tumor microenvironment, including molecular, cellular, and tissue scales, is presented. In this model, important aspects of tumor microenvironmental dynamics including tumor growth, angiogenesis, cancer metabolism, and...
Investigation of flow dynamics in porous media using computer simulation
, Article 20th European Simulation and Modelling Conference, ESM 2006, Toulouse, 23 October 2006 through 25 October 2006 ; 2006 , Pages 157-163 ; Zamankhan, P ; Mousavi, S. M ; Pietarinen, K ; Sarkomaa, P ; Sharif University of Technology
EUROSIS
2006
Abstract
The aim of this work is to investigate flow hydrodynamics in porous media. Random non-overlapping spherical particles in a cylindrical geometry were produced as a porous media. Navier-Stokes equations in three-dimensional porous packed bed have been solved and dimensionless pressure drop has been studied for a fluid flow through the porous media at different Reynolds numbers (based on pore permeability and interstitial fluid velocity). The numerical results are in good agreement with those reported by Macdonald (1979) in the range of Reynolds numbers studied. At higher Reynolds numbers turbulent models such as large eddy simulation (LES) and Reynolds stress model (RSM) also have been...
Three-dimensional simulation of urine concentrating mechanism in a functional unit of rat outer medulla. I. Model structure and base case results
, Article Mathematical Biosciences ; Vol. 258 , 2014 , pp. 44-56 ; ISSN: 00255564 ; Saidi, M. S ; Saadatmand, M ; Banazadeh, M. H ; Firoozabadi, B ; Sharif University of Technology
Abstract
The urine formation and excretion system have long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happens in renal tissue. In this study, a novel three-dimensional approach is utilized for modeling the urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a detailed functional unit is proposed based on this specific configuration....