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Effects of hypertension on Intima-Media Thickness (IMT); application to a human carotid artery
, Article Scientia Iranica ; Volume 23, Issue 4 , 2016 , Pages 1731-1740 ; 10263098 (ISSN) ; Saidi, M. S ; Sohrabi, S ; Firoozabadi, B ; Banazadeh, M. H ; Sharif University of Technology
Sharif University of Technology
Abstract
A vast number of deaths in the world have been attributed to atherosclerosis. The prominent aim of this study is proposing an accurate and simple model to investigate the process of arterial wall thickening. In order to investigate LDL (Low Density Lipoprotein) accumulation in arterial wall, a four layer model for arterial wall consisting of endothelium, intima, IEL, and media is presented. All layers are treated as homogenous porous media. This model has been solved both numerically and analytically. Obtained accumulated LDL in the intima is used to calculate oxidized LDL flux. Also, the presented model and clinical data are used to prepare the growth model for arterial wall. Furthermore,...
A simple model of intimal thickening-effects of hypertension
, Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 276-281 ; 9781467331302 (ISBN) ; Saidi, M. S ; Firoozabadi, D ; Sharif University of Technology
2012
Abstract
A vast amount of death in the world has been attributed to atherosclerosis. This disease causes plaque formation and finally lack of blood supply to an organ. The prominent aim of this study is proposing an accurate and simple model to investigate the process of arterial wall thickening. In order to investigate LDL (low density lipoprotein) accumulation in arterial wall which is considered the first stage of atherosclerosis, a four layer model for arterial wall consisting of endothelium, intima, IEL and media is presented. All layers are treated as homogenous porous media. The four-layer arterial wall model is the most powerful and reliable tool for modeling LDL transport within arterial...
Patient-specific fluid–structure interaction simulation of the LAD-ITA bypass graft for moderate and severe stenosis: A doubt on the fractional flow reserve-based decision
, Article Biocybernetics and Biomedical Engineering ; Volume 42, Issue 1 , 2022 , Pages 143-157 ; 02085216 (ISSN) ; Firoozabadi, B ; Pakravan, H. A ; Ahmadi Tafti, S. H ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Fractional flow reserve (FFR)-based decision improves the outcomes of percutaneous coronary intervention (PCI) for some patients, while its effectiveness in improving the results of coronary artery bypass graft (CABG) is unclear, in particular for moderate stenosis. It may be due to the fact that FFR cannot take into account the impacts of competitive flow (CF), intimal hyperplasia (IH), as well as compliance mismatch (CMM). As a result, two questions arise 1) whether FFR is a sufficient factor to decide to perform the CABG for patients with moderate to severe stenosis or not and 2) whether post-operative FFR shows the effectiveness of a graft. To shed light on this matter, two...