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Effects of hypertension on Intima-Media Thickness (IMT); application to a human carotid artery
, Article Scientia Iranica ; Volume 23, Issue 4 , 2016 , Pages 1731-1740 ; 10263098 (ISSN) ; Saidi, M. S ; Sohrabi, S ; Firoozabadi, B ; Banazadeh, M. H ; Sharif University of Technology
Sharif University of Technology
Abstract
A vast number of deaths in the world have been attributed to atherosclerosis. The prominent aim of this study is proposing an accurate and simple model to investigate the process of arterial wall thickening. In order to investigate LDL (Low Density Lipoprotein) accumulation in arterial wall, a four layer model for arterial wall consisting of endothelium, intima, IEL, and media is presented. All layers are treated as homogenous porous media. This model has been solved both numerically and analytically. Obtained accumulated LDL in the intima is used to calculate oxidized LDL flux. Also, the presented model and clinical data are used to prepare the growth model for arterial wall. Furthermore,...
A simple model of intimal thickening-effects of hypertension
, Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 276-281 ; 9781467331302 (ISBN) ; Saidi, M. S ; Firoozabadi, D ; Sharif University of Technology
2012
Abstract
A vast amount of death in the world has been attributed to atherosclerosis. This disease causes plaque formation and finally lack of blood supply to an organ. The prominent aim of this study is proposing an accurate and simple model to investigate the process of arterial wall thickening. In order to investigate LDL (low density lipoprotein) accumulation in arterial wall which is considered the first stage of atherosclerosis, a four layer model for arterial wall consisting of endothelium, intima, IEL and media is presented. All layers are treated as homogenous porous media. The four-layer arterial wall model is the most powerful and reliable tool for modeling LDL transport within arterial...