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inverse-micro-emulsion
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Population balance modeling of barium sulfate nanoparticle synthesis via inverse microemulsion including coagulation effect
, Article Industrial and Engineering Chemistry Research ; Vol. 53, issue. 32 , 2014 , Pages 12705-12719 ; ISSN: 08885885 ; Shahrokhi, M ; Molaei Dehkordi, A ; Sharif University of Technology
Abstract
A deterministic model based on the discrete population balance equation (PBE) is used to examine the precipitation of barium sulfate nanoparticles in nonionic inverse microemulsion systems. It is shown that coagulation can have a significant effect at low initial reactants concentration. The simulation results show that a bimodal particle size distribution (PSD) observed in experimental analysis reported in the literature cannot be predicted by neglecting the coagulation effect. A coagulation kernel is proposed that takes into account the effect of interparticle forces through the Fuchs' stability ratio. The effect of electrolyte concentration on the surfactant headgroup area is also...
Enzymatically crosslinked hyaluronic acid microgels as a vehicle for sustained delivery of cationic proteins
, Article European Polymer Journal ; Volume 115 , 2019 , Pages 234-243 ; 00143057 (ISSN) ; Abdekhodaie, M. J ; Mousavi, A ; Zoetebier, B ; Dijkstra, P. J ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
In this study, a novel biodegradable hyaluronic acid (HA) based microgel were prepared via enzymatic crosslinking of tyramine conjugated HA (HA-TA) in an inverse microemulsion. HA-TA microdroplets were crosslinked within a few seconds in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H 2 O 2 ). The high water content of the polymeric network and the inherent negative charge of the HA-TA microgels provided a suitable platform for encapsulation of cationic proteins like lysozyme and TGF-β1 growth factor. The results demonstrated that lysozyme was released, after an initial burst release, in a suitable sustained manner over a period of four weeks. Both diffusion and...