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    A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 75, Issue 1 , 1 January , 2010 , Pages 300–309 Mahmoudi, M. (Morteza) ; Simchi, A. (Abdolreza) ; Imani, M. (Mohammad) ; Shokrgozar, M. A. (Mohammad A.) ; Milani, A. S. (Abbas S.) ; Hafeli, Urs O ; Stroeve, Pieter ; Sharif University of Technology
    Abstract
    Superparamagnetic iron oxide nanoparticles (SPIONs) are increasingly used in medical applications, such as targeting delivery and imaging. In the future, patients are more likely to be exposed to pharmaceutical products containing such particles. The study of toxicity of SPIONs has become of great importance in recent years, although the published data in this arena is limited. The aim of the present work is to investigate the cytotoxicity of SPIONs and the effect of the particles on the cell medium components. For this purpose, uncoated and polyvinyl alcohol (PVA) coated SPIONs with narrow size distribution were synthesized via a well-known coprecipitation method. The mouse fibroblast cell... 

    Synthesis, characterization and biological evaluation of a well dispersed suspension of gallium-68-labeled magnetic nanosheets of graphene oxide for in vivo coincidence imaging

    , Article Radiochimica Acta ; Volume 105, Issue 1 , 2017 , Pages 65-73 ; 00338230 (ISSN) Fazaeli, Y ; Rahighi, R ; Tayyebi, A ; Feizi, S ; Sharif University of Technology
    Walter de Gruyter GmbH  2017
    Abstract
    Graphene oxide (GO) nanosheets were hybridized with Fe3O4 nanoparticles (NPs) to form magnetic GO (MGO) and were further labeled by [68Ga]GaCl3 as a potential drug delivery system. Paper chromatography, Fourier transform infra red (FTIR) spectroscopy, low-angle X-ray diffraction (XRD), CHN and atomic force microscopy (AFM) were utilized to characterize the trinary composite ([68Ga]@MGO). Biological evaluations of the prepared nanocomposite were performed in normal Sprague Dawley rats and it was found to be a possible host for theranostic radiopharmaceuticals. The results showed that the grafting of Fe3O4 NPs on nanocomposite reduced the unwanted liver and spleen uptakes and increased the... 

    Activation of hydrocarbon C-H bonds by iodosylbenzene: How does it compare with iron(iv)-oxo oxidants?

    , Article Chemical Communications ; Issue 12 , 2009 , Pages 1562-1564 ; 13597345 (ISSN) Kim, S. J ; Latifi, R ; Kang, H. Y ; Nam, W ; De Visser, S. P ; Sharif University of Technology
    2009
    Abstract
    Combined experimental and theoretical studies on the reactivity of iodosylbenzene (PhIO) show that PhIO is capable of activating weak C-H bonds of hydrocarbons via a hydrogen abstraction mechanism. © 2009 The Royal Society of Chemistry  

    Preparation and biological evaluation of [67 Ga]-labeled-superparamagnetic iron oxide nanoparticles in normal rats

    , Article Journal of Nuclear Science and Technology ; Volume 97, Issue 1 , September , 2009 , Pages 51–56 Jalilian, A. R ; Panahifar, A ; Mahmoudi, M. (Morteza) ; Akhlaghi, M. (Mahdi) ; Simchi, A. (Abdolreza) ; Sharif University of Technology
    Abstract
    Gallium-67 labeled superparamagnetic iron oxide nanoparticles were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles with narrow size distribution were synthesized by co-precipitation technique using ferric and ferrous salts at molar ratio Fe3+/Fe2+=2:1 followed by structure identification using XRD, thermo gravimetric analysis , differential scanning calorimetric , vibrating sample magnetometer, high-resolution scanning electron microscopy,transmission electron microscopy and fourier transform infrared absorption techniques. In order to trace superparamagnetic iron oxide nanoparticles bio-distribution, the radiolabeled iron... 

    Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

    , Article Journal of the Iranian Chemical Society ; Volume 7, Issue SUPPL. 1 , 2010 , Pages S1-S27 ; 1735207X (ISSN) Mahmoudi, M ; Simchi, A ; Imani, M ; Sharif University of Technology
    2010
    Abstract
    Superparamagnetic iron oxide nanoparticles (SPIONs) are promising materials for various biomedical applications including targeted drug delivery and imaging, hyperthermia, magneto-transfections, gene therapy, stem cell tracking, molecular/cellular tracking, magnetic separation technologies (e.g. rapid DNA sequencing), and detection of liver and lymph node metastases. The most recent applications for SPIONs for early detection of inflammatory, cancer, diabetes and atherosclerosis have also increased their popularity in academia. In order to increase the efficacy of SPIONs in the desired applications, especial surface coating/characteristics are required. The aim of this article is to review... 

    Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

    , Article Journal of the Iranian Chemical Society ; Volume 7, Issue 2 , July , 2010 , pp. S1-S27 ; 1735-2428 Mahmoudi, M ; Simchi, A. (Abdolreza) ; Imani, M ; Sharif University of Technology
    Abstract
    Superparamagnetic iron oxide nanoparticles (SPIONs) are promising materials for various biomedical applications including targeted drug delivery and imaging, hyperthermia, magneto-transfections, gene therapy, stem cell tracking, molecular/cellular tracking, magnetic separation technologies (e.g. rapid DNA sequencing), and detection of liver and lymph node metastases. The most recent applications for SPIONs for early detection of inflammatory, cancer, diabetes and atherosclerosis have also increased their popularity in academia. In order to increase the efficacy of SPIONs in the desired applications, especial surface coating/characteristics are required. The aim of this article is to review... 

    Preparation and biological evaluation of [67Ga]-labeled- superparamagnetic nanoparticles in normal rats

    , Article Radiochimica Acta ; Volume 97, Issue 1 , 2009 , Pages 51-56 ; 00338230 (ISSN) Jalilian, A. R ; Panahifar, A ; Mahmoudi, M ; Akhlaghi, M ; Simchi, A ; Sharif University of Technology
    R. Oldenbourg Verlag GmbH  2009
    Abstract
    Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe3+/Fe2+ = 2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈ 5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The... 

    Efficiency of copper bioleaching of two mesophilic and thermophilic bacteria isolated from chalcopyrite concentrate of Kerman-Yazd regions in Iran

    , Article Scientia Iranica ; Volume 14, Issue 2 , 2007 , Pages 180-184 ; 10263098 (ISSN) Mousavi, S. M ; Yaghmaei, S ; Vossoughi, M ; Jafari, A ; Sharif University of Technology
    Sharif University of Technology  2007
    Abstract
    A mesophilic iron oxidizing bacterium, Acidithiobacillus ferrooxidans, has been isolated (33°C) from a typical chalcopyrite copper concentrate of the Sarcheshmeh Copper Mine in the region of Kerman located in the south of Iran. In addition, a thermophilic iron oxidizing bacterium, Sulfobacillus spp., has been isolated (60°C) from the Kooshk Lead and Zinc Mine near the city of Yazd in the mid-west region of Iran. The variation of pH, ferrous and ferric concentration and cell growth on the time and effects of some factors, such as temperature and initial ferrous concentration, on the bioleaching of chalcopyrite concentrate obtained from Sarcheshmeh Copper Mine, were investigated. Bioleaching... 

    Fe3O4 Nano Particle-Based Magnetic Solid Phase Extraction of Oxadiargy1 and Fluoxetine from Aquatic and Biological Media

    , M.Sc. Thesis Sharif University of Technology Zandi, Omid (Author) ; Bagheri, Habib (Supervisor)
    Abstract
    In this study new magnetic solid phase extraction (MSPE) methods based on Fe3O4 magnetic nanoparticles (NPs) for extraction and preconcentration of oxadiargyl and fuoxetine from aqueous and biological samples were developed. In the first work, Fe3O4 NPs was successfully used as a magnetic nano-sorbent in magnetic micro-solid phase extraction (M-µ-SPE) of oxadiargyl, a newly used pesticide, from environmental water samples prior to gas chromatography-mass spectrometry determination. Oxadiargyl in mild acidic condition has tendency to be adsorbed on Fe3O4 NPs surfaces. Most important parameters that affect the extraction efficiency were also studied. Under optimized condition, the proposed... 

    Surface Modification of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs)for Cell Separation

    , M.Sc. Thesis Sharif University of Technology Shirzadeh, Ghazale (Author) ; Maddah Hoseini, Hamid Reza (Supervisor)
    Abstract
    The aim of this project is the surface modification of super para magnetic iron oxide (SPIONs), leading to oriented covalent bonding of antibody(AB) to these nanoparticles (NPs) and improve the efficiency of cell separation at MACS columns. For this purpose, SPIONs synthesized by co-precipitation method, and the stability of colloidal NPs then was provided by coating with Dextran . We used TGA to measure weight percentage of dextran. Some properties like particle size, hydrodynamic diameter, presence of coating and superparamagnetic properties were characterized by XRD (16 nm), FTIR, DLS (73 nm), TEM (20nm) and VSM (≈76/78 emu/g) method, respectively. Then we tried to immobilize AB on NPs... 

    The Impact of Nano-conjugation of Geinstein as Chemotherapeutic Agent against Cancer

    , M.Sc. Thesis Sharif University of Technology Ghasemi, Rachel (Author) ; Mohammadi, Mohammad Reza (Supervisor)
    Abstract
    With development of nanotechnology in medicine, nanoparticles are used for detection of tumor and cancer biomarkers. Magnetic nanoparticles are widely used for therapeutic and diagnostic objectives, because of their biocompatibility, ease of preparation and strong magnetic properties. Genistein (C15H10O5) is a soy isoflavone which is used for its anti-cancer activities. It is used for inhibition of cell proliferation, cell growth, and tumor invasion. The aim of this study is to assess the impact of nano-conjugation of geinstein as chemotherapeutic agent against cancer. For preparation of typical iron oxide Nanoparticles, Magnetite nanoparticles were synthesized by coprecipitating iron (II)... 

    Unprecedented selective oxidation of styrene derivatives using a supported iron oxide nanocatalyst in aqueous medium

    , Article Advanced Synthesis and Catalysis ; Volume 354, Issue 9 , 2012 , Pages 1707-1711 ; 16154150 (ISSN) Rajabi, F ; Karimi, N ; Saidi, M. R ; Primo, A ; Varma, R. S ; Luque, R ; Sharif University of Technology
    2012
    Abstract
    Iron oxide nanoparticles supported on mesoporous silica-type materials have been successfully utilized in the aqueous selective oxidation of alkenes under mild conditions using hydrogen peroxide as green oxidant. The supported catalyst could be easily recovered after completion of the reaction and reused several times without any loss in activity (no metal leaching observed during the reaction), constituting a facile and straightforward example of aqueous oxidation chemistry promoted by iron-based heterogeneous systems. Copyright  

    Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy

    , Article Chemical Papers ; 2020 Hedayatnasab, Z ; Dabbagh, A ; Abnisa, F ; Karimian, H ; Abu Kasim, N. H ; Wan Daud, W. M. A ; Sharif University of Technology
    Springer  2020
    Abstract
    Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as promising magnetic nanoheating agents for diagnostic as well as therapeutic applications due to their biocompatibility and tunability of magnetic properties. These nanoheating agents are commonly synthesized by coprecipitation of two iron precursors, though applying less amount of these chemicals may minimize the toxicity risks for biomedical purposes. The aim of this study is to address this issue by considering the high oxidation vulnerability of ferrous ions to ferric ions to synthesize SPIONs via a single-iron precursor under four varied oxidative conditions. The obtained results implied that the properties... 

    A novel binuclear iron(III)-salicylaldazine complex; synthesis, X-ray structure and catalytic activity in sulfide oxidation

    , Article Polyhedron ; Volume 183 , June , 2020 Mesbahi, E ; Bagherzadeh, M ; Amini, M ; Akbari, A ; Ellern, A ; Woo, L. K ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    A novel binuclear iron(III)-salicylaldazine complex has been synthesized and characterized by various techniques such as IR and UV–Vis spectroscopy and X-ray crystallography. The catalytic oxidation of sulfides in the presence of the aforementioned complex was explored at room temperature using urea hydrogen peroxide (UHP) as an oxidant. Effects of different reaction conditions consisting catalyst and oxidant amount, solvent effect and reaction time on the catalytic activity and selectivity in the reaction of methylphenylsulfide oxidation has been surveyed. Perfect selectivity toward sulfoxide was achieved after 15 min in CH3CN by choice of a properly optimized reaction condition. © 2020... 

    Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy

    , Article Chemical Papers ; Volume 75, Issue 2 , 2021 , Pages 669-679 ; 03666352 (ISSN) Hedayatnasab, Z ; Dabbagh, A ; Abnisa, F ; Karimian, H ; Abu Kasim, N. H ; Wan Daud, W. M. A ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2021
    Abstract
    Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as promising magnetic nanoheating agents for diagnostic as well as therapeutic applications due to their biocompatibility and tunability of magnetic properties. These nanoheating agents are commonly synthesized by coprecipitation of two iron precursors, though applying less amount of these chemicals may minimize the toxicity risks for biomedical purposes. The aim of this study is to address this issue by considering the high oxidation vulnerability of ferrous ions to ferric ions to synthesize SPIONs via a single-iron precursor under four varied oxidative conditions. The obtained results implied that the properties... 

    The Effects of Residence Time, Temperature and Particle size in Partially Reduction of Hematite to Magnetite VIA Fluidized bed Furnace

    , M.Sc. Thesis Sharif University of Technology Ahmadi, Alireza (Author) ; Halai, Mohammad (Supervisor)
    Abstract
    The Effects of temperature, residence time and particle size has been investigated on partial reduction of hematite to magnetite VIA fluidized bed reactor. Since there is water crisis in Iran, it is not rational to use gravity separation processes. Rather the best way is to use magnetic separation. Ghazvin’s region non-coking coal was used for gasifying step in various temperatures in order to produce the gas reduction agent. Golgohr’s mine waste concentrate were tested as the initial iron ore. For the very first time, the residence time of the particles were investigated by the change of height of reaction chamber, in 3 different heights, and the highest i.e. 15 cm had the best results. As... 

    Synthesis and Biological Evaluation of Magnetic Colloids of Ultrasmall Super Paramgnetic Iron Oxide Nanoparticles for Biomedical Applications

    , M.Sc. Thesis Sharif University of Technology Abedini, Fatemeh (Author) ; Maddah Hosseini, Hamid Reza (Supervisor) ; Shokrgozar, Mohammad Ali (Supervisor)
    Abstract
    Present study is designed to determine the effect of manganese content in primitive inverse spinel structure of iron oxide nanoparticles. PEG coated water base ferrofluids of Mnx¬Fe3-xO4 (0<0>1)nanoparticles were prepared by co-precipitation method in presence of nitrogen gas and ultrasonic waves using NaOH as a base for biomedical purposes. The crystallite size and structure of synthesized nanoparticles were studied using atomic absorption spectroscopy (AAS), X-ray diffraction spectrometry (XRD), field emission scanning electron microscopy (FE-SEM) and dynamic light scattering (DLS) methods. Thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) were used to... 

    Synthesis of Mesoporous Silica-Magnetite Nanocopmposite for Biological Applications

    , M.Sc. Thesis Sharif University of Technology Bagherzadeh, Elham (Author) ; Madaah Hosseini, Hamid Reza (Supervisor)
    Abstract
    During the most recent years, investigating novel nanomaterials based on porous strucures has become an interesting field of research. Among these kinds of materials, mesoporous silica has extensive applications in catalysis, absorbants and biomedical engineering. By combining specific surface characteristics of mesoporous silica with magnetic properties of iron oxide nanoparticles, new nanocomposites owing unique properties, can be obtained. In the present research, magnetic mesoporous nanocomposite has been synthesized. Iron oxide nanoparticles were produced through reduction of water solution containing Fe2+/Fe3+ ions, followed by hydrothermal treatment of precipitan. Then, iron oxide... 

    Synthesis and Electrochemical Characterization of Graphene Based Nanocomposites Containing Iron oxide and Titanium dioxide and Use them as Electrodes in Asymmetric Supercapacitors

    , M.Sc. Thesis Sharif University of Technology Abbasali Karajabad, Zeinab (Author) ; Nemati, Ali (Supervisor) ; Faghihi Sani, Mohammad Ali (Supervisor)
    Abstract
    Transition metal oxides and carbon based materials (especially graphene) are common electrode materials in supercapacitors. The metal oxide limitation is due to their high agglomeration and low electrical conductivity. On the other hand graphene base materials due to their unique structure as well as high electrical conductivity and high surface area increase energy storage capability. However, chemically produced graphene generally suffers from high agglomeration and re-stacking after removal from the solution and drying, g, which results in reduced electrochemical performance of graphene sheets in supercapacitors. To take full advantage of these two groups of materials, it is expected that... 

    Ethylbenzene dehydrogenation to styrene over fresh and used commercial catalysts

    , Article AIChE Annual Meeting, Conference Proceedings ; 2011 ; 9780816910670 (ISBN) Baghalha, M ; Ebrahimpour, O ; Sharif University of Technology
    2011
    Abstract
    Dehydrogenation of ethylbenzene (EB) to produce styrene (ST) monomer is commercially performed over potassium-promoted iron oxide catalysts. Catalyst deactivation due to coke deposition and loss of potassium is a major operation and economic drawback in this process. To better evaluate the performance change of these catalysts over their life-cycle, dehydrogenation of EB to ST over the fresh and used commercial catalysts was experimentally investigated at temperatures from 590 to 639°C under atmospheric pressure. The fresh and the used catalysts were obtained from a styrene plant. The used catalyst had been continuously operated for two years under severe plant conditions. The catalyst...