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    A Mathematical Model to Investigate the Advantages of Participation of the Compatible Pairs in Kidney Exchange Programs

    , M.Sc. Thesis Sharif University of Technology Abbasi, Mohammad Hossein (Author) ; Najafi, Mehdi (Supervisor)
    Abstract
    In the current situation, kidney transplantation is the most appropriate and least costly treatment for patients with end-stage renal disease (ESRD). Related or altruistic living donors, as well as deceased donors, are considered as a supply source for donated kidneys. Researches have shown deceased donor kidney may not work as well as a living donor kidney because the deceased donor kidney is outside the donor's body for a longer time. If the donor has an incompatibility with the patient (in terms of the blood group, HLA, etc.), a kidney exchange between the pairs can be used to resolve the issue and make the transplantation possible. Pairs with blood group compatibility have also... 

    A Mathematical Model to Organize Transplants in a Kidney Exchange Program with Uncertain Failures

    , M.Sc. Thesis Sharif University of Technology Porbar, Gohar (Author) ; Najafi, Mehdi (Supervisor) ; Shadrokh, Shahram (Supervisor)
    Abstract
    Kidney transplants are vital for patients with end-stage kidney disease. Therefore, it is essential to allocate kidneys to patients efficiently. Kidney Exchange Programs allow patients with incompatible donors to exchange donors and receive a suitable kidney. In practice, these exchanges occur within cyclic or chain-like structures. Planned transplants may be canceled before the transplant takes place, for a variety of reasons. Failure of one transplant in a cycle or chain can result in the failure of all transplants in that cycle or chain, which can lead to drastic inefficiency in the exchange program.In this thesis, we study kidney exchange programs under uncertainty. We consider... 

    An Application of Mathematical Programming in Kidney Exchange Problem

    , M.Sc. Thesis Sharif University of Technology Talei, Alireza (Author) ; Eshghi, Kourosh (Supervisor)
    Abstract
    One of the most efficient techniques deployed for end-stage renal disease remedy is kidney transplantation, but in this case, we commonly encounter with the problem of gap between the demand of patients and supply of donors. In the majority of models has been proposed until now, either kidney exchange technique in a pool of incompatible pairs or kidney allocation system from deceased donors to waiting list is recommended. In this research, in order to enhance kidney transplantation plans, first, a hybrid conceptual model is proposed. Then, its mathematical model is discussed, in which some of the transplantations are selected from kidney allocation system before injecting to the pool of... 

    A Mathematical Model to Apportion the Cost of Kidney Purchasing in Domino-paired Donation

    , M.Sc. Thesis Sharif University of Technology Hosseinzadeh, Arian (Author) ; Najafi, Mehdi (Supervisor)
    Abstract
    The human body normally has two functioning kidneys, while only one of them is sufficient to have a healthy life. However, for those patients having no functioning kidney, transplantation is the most effective treatment. Although deceased donors have been usually used as the main source for kidney donation in many countries, there are several cases focusing on living kidney donation to compensate for the shortage in supply and to reduce the patient waiting time for treatment. Because of this potential, many studies have been conducted to optimize the non-clinical issues of kidney transplant waiting lists. Notwithstanding employing the financial incentives for living kidney donation is... 

    A Data-Driven Optimization Methodology to Improve Unmatched Pairs Assignment in Kidney Exchange Problem

    , M.Sc. Thesis Sharif University of Technology Dadashi, Hossein (Author) ; Najafi, Mahdi (Supervisor) ; Rafiee, Majid (Supervisor)
    Abstract
    One of the most common and effective ways to treat end-stage renal disease is the use of kidney exchange techniques. However, the main problem with this treatment is the presence of many barriers to allocating kidney pairs to each other, which reduces the success of kidney transplants. Among different types of kidney transplantation methods, the present study utilizes kidney transplantation cycles to develop the allocation of unmatched pairs in kidney transplantation using a data-driven optimization technique. In this study, HLA patients were considered as simulated and also a two-objective model in the kidney exchange network was designed to maximize the probability of kidney...