Loading...
Search for:
l-3--4-dihydroxyphenylalanine
0.005 seconds
Simple and rapid detection of L-dopa based on in situ formation of polylevodopa nanoparticles
, Article Sensors and Actuators, B: Chemical ; Volume 243 , 2017 , Pages 715-720 ; 09254005 (ISSN) ; Moslehipour, A ; Bigdeli, A ; Sharif University of Technology
Elsevier B.V
2017
Abstract
Levodopa [L-3, 4-dihydroxyphenylalanine, or L-DOPA] is an important neurotransmitter used for the treatment of neural disorders such as Parkinson's disease. Abnormal L-Dopa concentrations in biological fluids can be used for the evaluation of such diseases. In this work, a rapid and sensitive method for L-DOPA detection has been reported which is based on in situ formation of polylevodopa nanoparticles. Under alkaline conditions, L-DOPA is spontaneously oxidized to its quinone derivative and shows fluorescence properties. The fluorescence signal of the oxidation product has been monitored and used for the determination of L-DOPA in the presence of dopamine, uric acid, ascorbic acid and other...