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l-dopa
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Simple and rapid detection of L-dopa based on in situ formation of polylevodopa nanoparticles
, Article Sensors and Actuators, B: Chemical ; Volume 243 , 2017 , Pages 715-720 ; 09254005 (ISSN) ; Moslehipour, A ; Bigdeli, A ; Sharif University of Technology
Elsevier B.V
2017
Abstract
Levodopa [L-3, 4-dihydroxyphenylalanine, or L-DOPA] is an important neurotransmitter used for the treatment of neural disorders such as Parkinson's disease. Abnormal L-Dopa concentrations in biological fluids can be used for the evaluation of such diseases. In this work, a rapid and sensitive method for L-DOPA detection has been reported which is based on in situ formation of polylevodopa nanoparticles. Under alkaline conditions, L-DOPA is spontaneously oxidized to its quinone derivative and shows fluorescence properties. The fluorescence signal of the oxidation product has been monitored and used for the determination of L-DOPA in the presence of dopamine, uric acid, ascorbic acid and other...
Electrochemical determination of l-dopa in the presence of ascorbic acid on the surface of the glassy carbon electrode modified by a bilayer of multi-walled carbon nanotube and poly-pyrrole doped with tiron
, Article Journal of Electroanalytical Chemistry ; Volume 636, Issue 1-2 , 2009 , Pages 40-46 ; 15726657 (ISSN) ; Asadian, E ; Sharif University of Technology
Elsevier
2009
Abstract
There are high attractions in the development of conducting polymer (CP) coatings to improve the electrochemical properties and biocompatibility of electrodes in the area of biosensors. A new type of the modified electrodes is prepared in a layer-by-layer process by using multi-walled carbon nanotube (MWCNT) and poly-pyrrole. In this procedure, the glassy carbon electrode is casted by a drop suspension of MWCNT, which leads to form a thin film of nanotube on its surface. In the second step, electrochemical polymerization of pyrrole in the presence of tiron (used as doping anion) is performed on the surface of the MWCNT pre-coated electrode. The modification procedure led to fabrication of a...