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    Fluids Flow Simulation in the Cell Influenced the Focal Adhesions

    , Ph.D. Dissertation Sharif University of Technology Nikmaneshi, Mohammad Reza (Author) ; Firoozabadi, Bahar (Supervisor) ; saidi, Mohammad said (Co-Advisor)
    Abstract
    In the present thesis, intracellular fluid flows have investigated for study cell motions. It is due to firmly relation between the cell motion and these flows. Generally, the cell firstly adheres to a surface, then, moves forward with the effects of the internal fluid flows. In this study, the cell structure is invided to two general parts; the front part of the cell and the cell body. The front part of the cell plays a essential roles in the cell motion, however, the cell body is considered as a extra cargo that is carried by the front of the cell. Therefor, in the present modellings, the front part is only considered. Here, using four different models for the front part of the cell, many... 

    Studies of the Interaction between Actins Flow and Cell Adhesion Nucleation in Macro-and Micro-scale

    , Ph.D. Dissertation Sharif University of Technology Ghasemi Varnamkhasti, Amir (Author) ; Firouzabadi, Bahar (Supervisor) ; Saeedi, Mohammad Saeed (Supervisor)
    Abstract
    The network of actin filaments is one of the three elements of the Cytoskeleton and plays a role in cell shape and migration. The actin network is dynamic; it (de)polymerizes, and in migrating and spreading cells, it is in a retrograde motion from the cell periphery toward cell nucleus. Adhesion points, which link the cytoskeleton to the extracellular matrix, interact with the actin retrograde flow. Actin filaments can be identified in two distinct regions in which their structure, flow velocity, driving force and size of the adhesions are different; the outer region is called Lamellipodium and the inner one Lamellum. In macro scale and regarding spreading cells, considering adhesions...