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Heat Transfer Modeling of Ultrasounic Hyperthermia
, M.Sc. Thesis Sharif University of Technology ; Jahed, Mehran (Supervisor)
Abstract
Ultrasound hyperthermia is a commonly used noninvasive approach to destroy cancer tumors. High Intensity Focused Ultrasound (HIFU) is a technique based on hyperthermia. It creates short and local elevations of temperature at a focus site within the tissue of interest. The main goal of HIFU is to maintain the temperature between 50 and 100 °C for a few seconds (typically less than 10 s), in order to cause tissue necrosis. In order to predict the effects of hyperthermia, accurate and effective modeling is needed. This study considers a 3D simulation of the hyperthermia based on HIFU method in the liver tissue. Temperature distribution and lesion volume changes, with a temperature of above...
Mathematical study of probe arrangement and nanoparticle injection effects on heat transfer during cryosurgery
, Article Computers in Biology and Medicine ; Volume 66 , Nov , 2015 , Pages 113-119 ; 00104825 (ISSN) ; Ramazani S. A. A ; Nazemidashtarjandi, S ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Blood vessels, especially large vessels have a greater thermal effect on freezing tissue during cryosurgery. Vascular networks act as heat sources in tissue, and cause failure in cryosurgery and reappearance of cancer. The aim of this study is to numerically simulate the effect of probe location and multiprobe on heat transfer distribution. Furthermore, the effect of nanoparticles injection is studied. It is shown that the small probes location near large blood vessels could help to reduce the necessary time for tissue freezing. Nanoparticles injection shows that the thermal effect of blood vessel in tissue is improved. Using Au, Ag and diamond nanoparticles have the most growth of ice ball...
Prediction of temperature distribution and volume of lesion during HIFU therapy
, Article ITNG 2009 - 6th International Conference on Information Technology: New Generations, 27 April 2009 through 29 April 2009, Las Vegas, NV ; 2009 , Pages 1468-1473 ; 9780769535968 (ISBN) ; Jahed, M ; Sharif University of Technology
Abstract
Ultrasound hyperthermia is used to treat tumors in human tissue by heat. It is characterized by the application of high intensity focused ultrasound (HIFU), high local temperatures and short treating time of a few seconds. HIFU is a non-invasive treatment modality for a variety of cancers, including breast, prostate, kidney, liver, bone, uterus, and pancreatic cancers. Computer models have been used to determine tissue temperatures during ultrasound hyperthermia. In this work, we consider a liver tissue with a tumor at its center. We calculated temperature distribution in the presence a large blood vessel. We studied the effect of varying the exposure time (heating duration) and the diameter...