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Flexural sensitivity of a V-shaped AFM cantilever made of functionally graded materials
, Article ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis, ESDA2010, 12 July 2010 through 14 July 2010 ; Volume 1 , 2010 , Pages 495-501 ; 9780791849156 (ISBN) ; Kahrobaiyan, M. H ; Moeini, S. A ; Ahmadian, M. T ; Hoviattalab, M ; Sharif University of Technology
Abstract
In this paper, two lowest resonant frequencies and sensitivities of an AFM V-Shaped microcantilever made of functionally graded materials are studied. The beam is modeled by Euler-Bernoulli beam theory in which rotary inertia and shear deformation is neglected. It is assumed that the beam is made of a mixture of metal and ceramic with properties varying through the thickness of the beam. This variation is function of volume fraction of beam material constituents. The interaction between AFM tip and surface is modeled by two linear springs which expresses the normal and lateral contact stiffness. A relationship is developed to evaluate the sensitivity of FGM micro cantilever beam. Effect of...
Nonlinear vibration of rectangular atomic force microscope cantilevers by considering the Hertzian contact theory
, Article Canadian Journal of Physics ; Volume 88, Issue 5 , 2010 , Pages 333-348 ; 00084204 (ISSN) ; Zohoor, H ; Sharif University of Technology
Abstract
The nonlinear flexural vibration for a rectangular atomic force microscope cantilever is investigated by using Timoshenko beam theory. In this paper, the normal and tangential tip-sample interaction forces are found from a Hertzian contact model and the effects of the contact position, normal and lateral contact stiffness, tip height, thickness of the beam, and the angle between the cantilever and the sample surface on the nonlinear frequency to linear frequency ratio are studied. The differential quadrature method is employed to solve the nonlinear differential equations of motion. The results show that softening behavior is seen for most cases and by increasing the normal contact...
Molecular dynamics simulation and MM-PBSA calculations of sickle cell hemoglobin in dimer form with Val, Trp, or Phe at the lateral contact
, Article Journal of Physical Organic Chemistry ; Volume 23, Issue 9 , March , 2010 , Pages 866-877 ; 08943230 (ISSN) ; Akbarzadeh, H ; Parsafar, G. A ; Sharif University of Technology
Abstract
As the delay time and hence nuclei formation play a crucial role in the pathophysiology of sickle cell disease, MD simulation and molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) calculations have been performed on three systems of hemoglobin; namely dimer of hemoglobin with valine (Hb S), tryptophan (Hbβ6W), and phenylalanine (Hbβ6F) at β6 position. The structural changes due to these aromatic substitutions are investigated. It is shown that β subunits have significant impact on the differences between a dimer and other crystal structures. Transition from a dimer to polymer for Hb S system affects the donor molecule more than that of the acceptor. In the case of donor and...