Sharif Digital Repository

Hemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting due to the lack of coagulation factors. Frequent joint and soft tissue bleeding is one the most common problems amongst these patients which can become progressively destructive for cartilage tissue in case of the late treatment. In this work, injectable PEG-based hydrogel nanocomposites with mechanical and structural properties close to cartilage tissue were fabricated. First, primary copolymers with PEG blocks of 600 g.mol-1 and 900 g.mol-1 without and with 2.5 wt.% Laponite nanoclay were synthesized by two-step thermal poly (amic acid) process. After polymer purification,... 

Implant-associated infections are one of the most serious complications in orthopaedic and trauma surgery as it may result in poor functional outcome, implant failure, chronic osteomyelitis or even death. Great concerns have been taken to reduce implant-associated infections through progressing in operating standards, minimizing the possibility of contamination during surgery, reducing the establishment of infection by perioperative antibiotic prophylaxis, and confining of pathogenic strains by patient isolation. In spite of these preventions, the percentage of postoperative infections is still rising. Composite coatings with bone-bioactivity and drug-eluting capacity are considered as...