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    Fabrication of a novel 3D scaffold for cartilage tissue repair: In-vitro and in-vivo study

    , Article Materials Science and Engineering C ; Volume 128 , 2021 ; 09284931 (ISSN) Haghighi, P ; Shamloo, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Self-repairing is not an advanced ability of articular cartilage. Tissue engineering has provided a novel way for reconstructing cartilage using natural polymers because of their biocompatibility and bio-functionality. The purpose of cartilage tissue engineering is to design a scaffold with proper pore structure and similar biological and mechanical properties to the native tissue. In this study, porous scaffolds prepared from gelatin, chitosan and silk fibroin were blended with varying ratios. Between the blends of chitosan (C), gelatin (G) and silk fibroin (S), the scaffold with the weight per volume ratio of 2:2:3 (w/v) showed the most favorable and higher certain properties than the... 

    Assessing the role of Ca2+ in skeletal muscle fatigue using a multi-scale continuum model

    , Article Journal of Theoretical Biology ; Volume 461 , 2019 , Pages 76-83 ; 00225193 (ISSN) Karami, M ; Calvo, B ; Zohoor, H ; Firoozbakhsh, K ; Grasa, J ; Sharif University of Technology
    Academic Press  2019
    The Calcium ion Ca2+ plays a critical role as an initiator and preserving agent of the cross-bridge cycle in the force generation of skeletal muscle. A new multi-scale chemo-mechanical model is presented in order to analyze the role of Ca2+ in muscle fatigue and to predict fatigue behavior. To this end, a cross-bridge kinematic model was incorporated in a continuum based mechanical model, considering a thermodynamic compatible framework. The contractile velocity and the generated active force were directly related to the force-bearing states that were considered for the cross-bridge cycle. In order to determine the values of the model parameters, the output results of an isometric simulation... 

    A microfabricated platform for the study of chondrogenesis under different compressive loads

    , Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 78 , 2018 , Pages 404-413 ; 17516161 (ISSN) Kowsari Esfahan, R ; Jahanbakhsh, A ; Saidi, M. S ; Bonakdar, S ; Sharif University of Technology
    Elsevier Ltd  2018
    Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture. Numerical simulations were performed to evaluate and optimize the design. Results showed a...