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Thermo- and pH-sensitive dendrosomes as bi-phase drug delivery systems
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 9, Issue 8 , 2013 , Pages 1203-1213 ; 15499634 (ISSN) ; Fard, A. K ; Abedi, F ; Chegeni, B. K ; Bani, F ; Sharif University of Technology
2013
Abstract
Fully supramolecular dendrosomes (FSD) as bi-phase drug delivery systems are reported in this work. For preparation of FSD, amphiphilic linear-dendritic supramolecular systems (ALDSS) have been synthesized by host-guest interactions between hyperbranched polyglycerol having β-cyclodextrin core and bi-chain polycaprolactone (BPCL) with a fluorescine focal point. Self-assembly of ALDSS in aqueous solutions led to FSD. They were able to encapsulate paclitaxel with a high loading capacity. The dendrosome-based drug delivery systems were highly sensitive to pH and temperature. They were stable at 20-37. °C and pH7-8, but dissociated and released drug at temperatures lower than 20. °C or higher...