Sharif Digital Repository

Several cyanohydrins were synthesized by the reaction of trimethylsilyl cyanide with carbonyl compounds in the presence of solid lithium perchlorate in high yields under solvent-free conditions. © 2003 Published by Elsevier B.V  

A new method has been developed for the direct conversion of epoxides to α-hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions. © 2003 Published by Elsevier Ltd  

The one-pot synthesis of several secondary amines and secondary amino esters are reported. Treatment of aldehydes (aliphatic or aromatic) with (trimethylsilyl)alkylamines, in the presence of 5 M lithium perchlorate in diethyl ether gives intermediate imines. Reaction of these intermediate imines with different nucleophiles and functionalized organozinc reagents, BrZnCH2COOR, produce a variety of secondary amines and N-alkyl- or N-arylamino esters in good yields. © 2001 Elsevier Science Ltd. All rights reserved  

A simple, rapid, and highly regioselective green protocols for the synthesis of β-hydroxylnitriles by the direct reaction of epoxides with trimethylsilyl cyanide in the presence of catalytic amount of lithium perchlorate under solvent free conditions in high to quantitative yield is reported  

The solid LiClO4-mediated one-pot reaction of aldehydes with secondary amines and C nucleophiles afforded the corresponding aminoalkylation products in high yields. Unlike the previous reported procedure, the aminoalkylation of aldehyde was achieved in the presence of only 0.5 equivalents of solid lithium perchlorate in dichloromethane as the solvent with good to high yields at room temperature. © Springer-Verlag 2003  

Several primary and secondary amines were added to α,β- unsaturated esters, nitriles, amides, and ketones to give the corresponding saturated amines mediated by solid lithium perchlorate under solvent-free and environmentally friendly conditions at room temperature. © 2003 Elsevier Ltd. All rights reserved  

A very mild, efficient and simple method for the synthesis of tertiary α-amino phosphonates is reported by reaction of an aldehyde, a secondary amine and trialkylphosphite in ethereal solution of lithium perchlorate, LPDE, at ambient temperature with high yields. © 2003 Elsevier Science Ltd. All rights reserved  

The α-hydroxy phosphonates are readily prepared by treating aromatic or aliphatic aldehydes and ketones with trialkylphosphite in the presence of trimethylsilylchloride in a very short time and in almost quantitative yields  

A three-component reaction between an aldehyde, metallated hexamethyldisilazane and a functionalized organozinc compound proceeded smoothly in the presence of LiClO4 in diethyl ether to afford primary amino esters in good yields  

Imines prepared in situ by reaction of aldehydes and ketones with primary amines in ethereal solution of LiClO4 react readily at ambient temperature with trialkylphosphite to give high yields of α-amino phosphonates  

Several aminovinyl phosphonates were prepared in good yield by four-component aminoalkylation of aldehydes with diethyl(trimethylsilyl)amine, triethylphosphite and dimethyl acetylenedicarboxylate mediated by a 5 molar solution of lithium perchlorate in diethyl ether  

A simple catalyst LiClO4/Et3N has been developed and demonstrated to efficiently catalyze Michael addition reactions of active methylene compounds to conjugated ketones, nitriles, esters and nitroalkenes with remarkably high yields and in short reaction time. The Michael addition to nitroalkenes and α,β-unsaturated ketones proceeds quantitatively in the usual way, giving the monoaddition product. © 2008 Elsevier B.V. All rights reserved  

A one-pot high yielding reductive amination of aldehydes with primary and secondary amines using LiClO4/NaBH4 and LiClO 4/LiAlH4 as reducing agents in diethyl ether is described  

A simple, rapid, atom economy and highly efficient green protocol has been developed for the reactions of indole with carbonyl compounds under solvent- free conditions. The attractive features of these procedures are the mild reaction conditions, high conversions, cleaner reaction profiles, inexpensive and environmentally friendly lithium perchlorate and short reaction times. © 2006 Bentham Science Publishers Ltd  

A simple, rapid, and highly regioselective green protocols for the synthesis of β-hydroxylnitriles by the direct reaction of epoxides with trimethylsilyl cyanide in the presence of catalytic amount of lithium perchlorate under solvent free conditions in high to quantitative yield is reported. © 2005 Elsevier B.V. All rights reserved  

A simple, efficient, and general synthetic strategy has been developed for the synthesis of Michael adducts in the presence of solid lithium perchlorate under solvent-free conditions. Nucleophilic addition of thiols and indoles gave the corresponding Michael adducts in high yields. © 2005 Taylor & Francis  

The reaction of substituted dithiocarbamates with electrophilic alkenes in the presence of LiClO4 was investigated in an attempt to prepare numerous ethyl dithiocarbamates bearing β-electron-withdrawing-group substituents. The reaction conditions are mild, neutral, with extremely simple work-up procedures, and offer high yield. © 2005 Taylor & Francis Group Ltd  

A three-component reaction between aliphatic or aromatic aldehyde, an amine and trimethylsilyl cyanide mediated by solid LiClO4, gave amino nitriles in good to excellent yields. The reaction proceeded smoothly under solvent-free conditions without any side products  

In situ prepared iminium salts are very effective electrophiles in Baylis-Hillman reactions and react with methyl acrylate in the presence of a catalytic amount of a tertiary amine at ambient temperatures to afford the corresponding Baylis-Hillman adducts. The product undergoes conjugated addition with (trimethylsilyl)dialkylamines to give the diamine 5 in good yields. © 2002 Elsevier Science Ltd. All rights reserved  

A one-pot, three-component, Mannich reaction of electron-rich aromatic compounds with in situ prepared iminium salts in 5 M ethereal lithium perchlorate gives good yields of aminoalkylated products at room temperature. © 2001 Elsevier Science Ltd. All rights reserved