Sharif Digital Repository

Various methods, such as those developed by the Medical Internal Radiation Dosimetry (MIRD) Committee of the Society of Nuclear Medicine or employing dose point kernels, have been applied to the radiation dosimetry of 131I radionuclide therapy. However, studies have not shown a strong relationship between tumour absorbed dose and its overall therapeutic response, probably due in part to inaccuracies in activity and dose estimation. In the current study, the GATE Monte Carlo computer code was used to facilitate voxel-level radiation dosimetry for organ activities measured in an . 131I-treated thyroid cancer patient. This approach allows incorporation of the size, shape and composition of... 

In this study, the influence of vascular bed comprising terminal arterial branches on heat transfer in a liver tumor exposed to high intensity focused ultrasound (HIFU) is studied numerically. Also, the effect of vascular density on temperature distribution is investigated. A coupled set of acoustics, thermal, and fluid models is used to calculate the temperature distribution in the liver. The numerical model is established based on the Westervelt and bioheat equations along with the Navier-Stokes equations. Moreover, the acoustic streaming effect is included with Newtonian and non-Newtonian flow assumptions. It is found that in a vascular bed comprising terminal arterial branches, the...