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    The importance of fluid-structure interaction simulation for determining the mechanical stimuli of endothelial cells and atheroprone regions in a coronary bifurcation

    , Article Scientia Iranica ; Volume 23, Issue 1 , 2016 , Pages 228-237 ; 10263098 (ISSN) Pakravan, H. A ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
    Sharif University of Technology  2016
    The function and morphology of Endothelial Cells (ECs) play a key role in atherosclerosis. The mechanical stimuli of ECs, such as Wall Shear Stress (WSS) and arterial wall strain, greatly inuence the function and morphology of these cells. The present article deals with computations of these stimuli for a 3D model of a healthy coronary artery bifurcation. The focus of the study is to propose an accurate method for computations of WSS and strains. Two approaches are considered: Coupled simultaneous simulation of arterial wall and blood flow, called fluid-Structure Interaction (FSI) simulation, and decoupled, which simulates each domain (fluid and solid domain) separately. The study... 

    A novel nonlinear constitutive relation for graphene and its consequence for developing closed-form expressions for Young's modulus and critical buckling strain of single-walled carbon nanotubes

    , Article Acta Mechanica ; Volume 222, Issue 1-2 , 2011 , Pages 91-101 ; 00015970 (ISSN) Shodja, H. M ; Delfani, M. R ; Sharif University of Technology
    Carbon nanotubes (CNTs) are viewed as rolled graphene. Thus, an appropriate formulation describing the behavior of CNTs must contain the key information about both their initial configuration as graphene and final configuration as CNT.On this note, to date, somemodels, in particular based on the Cauchy- Born rule, for the description of CNTs behavior exist. A simplifying assumption in some of these models is that the length and perimeter of the CNT equal the corresponding dimensions of the unrolled initial configuration, thus neglecting the induced hoop and longitudinal strains. On the other hand, the present work offers a purely nonlinear continuum model suitable for the description of the... 

    A multiscale approach for determining the morphology of endothelial cells at a coronary artery

    , Article International Journal for Numerical Methods in Biomedical Engineering ; Volume 33, Issue 12 , 2017 ; 20407939 (ISSN) Pakravan, H. A ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
    The morphology of endothelial cells (ECs) may be an indication for determining atheroprone sites. Until now, there has been no clinical imaging technique to visualize the morphology of ECs in the arteries. The present study introduces a computational technique for determining the morphology of ECs. This technique is a multiscale simulation consisting of the artery scale and the cell scale. The artery scale is a fluid-structure interaction simulation. The input for the artery scale is the geometry of the coronary artery, that is, the dynamic curvature of the artery due to the cardiac motion, blood flow, blood pressure, heart rate, and the mechanical properties of the blood and the arterial...