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lumbar-disk
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Computational pharmacokinetics of solute penetration into human intervertebral discs-Effects of endplate permeability, solute molecular weight and disc size
, Article Journal of Biomechanics ; Volume 45, Issue 13 , 2012 , Pages 2195-2202 ; 00219290 (ISSN) ; Shirazi Adl, A ; Urban, J. P. G ; Parnianpour, M ; Sharif University of Technology
Abstract
A finite element model is developed to predict the penetration time-history of three different solutes into the human lumbar disc following intravenous injection. Antibiotics are routinely administered intravenously in spinal surgery to prevent disc infection. Successful prophylaxis requires antibiotics to reach adequate inhibitory levels. Here, the transient diffusion of cephazolin is investigated over 10. h post-injection in a human disc model subject to reported concentrations in the blood stream as the prescribed boundary sources. Post-injection variation of cephazolin concentrations in the disc adjacent to supply sources closely followed the decay curve in the blood stream and fell...
Assessment of lumbar spinal disc injury in frontal crashes
, Article Computers in Biology and Medicine ; Volume 123 , 2020 ; Naserkhaki, S ; Parnianpour, M ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Frontal vehicle crashes have been a leading cause of spinal injuries in recent years. Reconstruction of frontal crashes using computational models and spinal load analysis helps us understand the patterns of injury and load propagation during frontal crashes. By reconstructing a real crash test and using a viscoelastic crash dummy model, spinal injury patterns were analyzed. The results indicated that a moderate crash with an impact speed of 56 km/h leads to injuries in L1-L2 and L5-S1 levels (L for lumbar and S for sacral vertebrae). The largest spinal loads and injuries were mainly observed immediately after the airbag deployment when the peak of the crash acceleration transpires. Also,...