Sharif Digital Repository

In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds. Drug loading efficiency and drug release behavior from... 

The nano metal-organic frameworks (NMOFs) have been developed for drug delivery systems due to their high porosity and large specific surface area. In this work, UiO-66-NH2 NMOFs were synthesized via the microwave heating method and doxorubicin (DOX) as an anticancer drug was incorporated into the UiO-66-NH2 NMOFs. Then, poly(N-vinylcaprolactam) (PNVCL) synthesized by the free radical polymerization was coated on the UiO-66-NH2 NMOFs surface to fabricate dual pH/temperature-responsive nanocomposite against A549 lung cancer cells death in vitro. The synthesized nanocarriers were characterized using FTIR, 1H NMR, DLS, XRD, SEM, FESEM, TGA, and BET analysis. The average particle sizes of... 

Early diagnosis of lung cancer is very important in improving patients life expectancies. Due to the high number of Computed Tomography (CT) images, fast and accurate diagnosis is difficult for radiologists. Therefore, there is an increasing demand for Computer-Aid Diagnosis (CAD) lung cancer. The core of all lung cancer detection systems is the distinction between cancer and non-cancerous tissues. This operation is performed in the false positive reduction phase, which is one of the most critical part of the lung cancer detection systems. The primary objective of this paper is to present a new method based on 3D Convolutional Neural Networks (CNN) that can reduce the false positives rate... 

Lung cancer is one of the most common diseases for human beings everywhere throughout the world. Early identification of this disease is the main conceivable approach to enhance the possibility of patients’ survival. In this paper, a k-Nearest-Neighbors technique, for which a genetic algorithm is applied for the efficient feature selection to reduce the dataset dimensions and enhance the classifier pace, is employed for diagnosing the stage of patients’ disease. To improve the accuracy of the proposed algorithm, the best value for k is determined using an experimental procedure. The implementation of the proposed approach on a lung cancer database reveals 100% accuracy. This implies that one... 

Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.... 

A chemiresistive sensor is described for the lung cancer biomarker hexanal. A composite consisting of molecularly imprinted polymer nanoparticles and multiwalled carbon nanotubes was used in the sensor that is typically operated at a voltage of 4 V and is capable of selectively sensing gaseous hexanal at room temperature. It works in the 10 to 200 ppm concentration range and has a 10 ppm detection limit (at S/N = 3). The sensor signal recovers to a value close to its starting value without the need for heating even after exposure to relatively high levels of hexanal  

Radon is released from soil and building materials and can accumulate in residential buildings. Breathing radon and radon progeny for extended periods hazardous to health and can lead to lung cancer. Indoor air conditions and ventilation systems strongly influence indoor radon concentrations. This paper focuses on effects of air change rate, indoor temperature and relative humidity on indoor radon concentrations in a one family detached house in Stockholm, Sweden.In this study a heat recovery ventilation system unit was used to control the ventilation rate and a continuous radon monitor (CRM) was used to measure radon levels. FLUENT, a computational fluid dynamics (CFD) software package was... 

In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds. Drug loading efficiency and drug release behavior from... 

Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malignancies ranging from hematological to solid tumors. One of the principal approaches of cancer immunotherapy is transfer of natural or engineered tumor-specific T-cells into patients, a so called "adoptive cell transfer", or ACT, process. Construction of allogeneic T-cells is dependent on the employment of a gene-editing tool to modify donor-extracted T-cells and prepare them to specifically act against tumor cells with enhanced function and durability and least side-effects. In this context, CRISPR technology can be used to produce universal T-cells, equipped with recombinant T cell...