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A selective chemiresistive sensor for the cancer-related volatile organic compound hexanal by using molecularly imprinted polymers and multiwalled carbon nanotubes
, Article Microchimica Acta ; Volume 186, Issue 3 , 2019 ; 00263672 (ISSN) ; Banan Nojavani, M ; Nikkhah, M ; Alizadeh, T ; Esfandiar, A ; Ganjali, M. R ; Sharif University of Technology
Springer-Verlag Wien
2019
Abstract
A chemiresistive sensor is described for the lung cancer biomarker hexanal. A composite consisting of molecularly imprinted polymer nanoparticles and multiwalled carbon nanotubes was used in the sensor that is typically operated at a voltage of 4 V and is capable of selectively sensing gaseous hexanal at room temperature. It works in the 10 to 200 ppm concentration range and has a 10 ppm detection limit (at S/N = 3). The sensor signal recovers to a value close to its starting value without the need for heating even after exposure to relatively high levels of hexanal
Fabrication of chitosan/poly(lactic acid)/graphene oxide/TiO2 composite nanofibrous scaffolds for sustained delivery of doxorubicin and treatment of lung cancer
, Article International Journal of Biological Macromolecules ; Volume 110 , 2018 , Pages 416-424 ; 01418130 (ISSN) ; Moradkhani, M ; Beheshti, H ; Irani, M ; Aliabadi, M ; Sharif University of Technology
Elsevier B.V
2018
Abstract
In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds. Drug loading efficiency and drug release behavior from...
Perylene diimide-POSS network for semi selective solid-phase microextraction of lung cancer biomarkers in exhaled breath
, Article Analytica Chimica Acta ; Volume 1198 , 2022 ; 00032670 (ISSN) ; Bagheri, H ; Yeganeh Rad, L ; Minaeian, S ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Lung cancer (LC) is the leading cause of cancer mortality so, the analysis of exhaled human breath has great significance for early non-invasive diagnosis. Poor selectivity and strong humidity are two bottlenecks for the application of gas sensors to exhaled breath analysis. The development of novel extractive phases for the analysis of exhaled breath by chromatography is therefore a lucrative object. Polyhedral oligomeric silsesquioxanes (POSS) are among the 3D porous materials whose unique properties make them promising coatings for solid-phase microextraction (SPME). Selective enrichment of polar or nonpolar targets depends on the pore size and functional groups on the POSSs. Herein, we...