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MIL-125-based nanocarrier decorated with Palladium complex for targeted drug delivery
, Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) ; Safarkhani, M ; Kiani, M ; Radmanesh, F ; Daneshgar, H ; Ghadiri, A. M ; Taghavimandi, F ; Fatahi, Y ; Safari-Alighiarloo, N ; Ahmadi, S ; Rabiee, N ; Sharif University of Technology
Nature Research
2022
Abstract
The aim of this work was to provide a novel approach to designing and synthesizing a nanocomposite with significant biocompatibility, biodegradability, and stability in biological microenvironments. Hence, the porous ultra-low-density materials, metal–organic frameworks (MOFs), have been considered and the MIL-125(Ti) has been chosen due to its distinctive characteristics such as great biocompatibility and good biodegradability immobilized on the surface of the reduced graphene oxide (rGO). Based on the results, the presence of transition metal complexes next to the drug not only can reinforce the stability of the drug on the structure by preparing π–π interaction between ligands and the...
Green synthesis of PEG-coated MIL-100(Fe) for controlled release of dacarbazine and its anticancer potential against human melanoma cells
, Article International Journal of Pharmaceutics ; Volume 618 , 2022 ; 03785173 (ISSN) ; Vossoughi, M ; Bagherzadeh, M ; Pooshang Bagheri, K ; Sharif University of Technology
Elsevier B.V
2022
Abstract
In this study, the potential of using MIL-100(Fe) metal–organic framework (MOF) for loading and controlling the release of dacarbazine (DTIC) was evaluated for in vitro treatment of melanoma. The drug loading was performed during the green synthesis of MIL-100(Fe) in an aqueous media without using any harmful solvents, to obtain MIL-DTIC. The surface of this structure was then coated with polyethylene glycol (PEG) in the same aqueous solution to synthesize MIL-DTIC-PEG. The synthesized samples were characterized using various methods. Their release profile was studied in phosphate-buffered saline (PBS) and simulated cutaneous medium (SCM). The cytotoxicity of DTIC and its nano-MOF...
Photocatalytic TiO2@MIL-88A (Fe)/polyacrylonitrile mixed matrix membranes: Characterization, anti-fouling properties, and performance on the removal of natural organic matter
, Article Chemosphere ; Volume 302 , 2022 ; 00456535 (ISSN) ; Mehdipour, M. H ; Fotovat, F ; Mousavi, S. A ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Photocatalytic membrane reactors (PMRs), coupling photocatalysts and membranes in a single system, have shown a considerable potential to reduce membrane fouling, which is one of the major drawbacks of using membranes to treat water and wastewater. In this study, the visible light-activated photocatalysts were incorporated into the polyacrylonitrile (PAN) casting solution to synthesize the photocatalytic composite membranes. The physicochemical properties and the morphology of the membranes and photocatalysts were characterized by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction analysis (XRD), ultraviolet–visible diffuse reflectance...