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malaria-diease
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In Silico Designing and Docking Evaluation of the Small Lectins to Inhibit Falciparum Attachment to the Midgut Epithelium of Anopheles Mosquito
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Raaz, Abbasali (Supervisor)
Abstract
The parasite entering into the blood of a malaria infected individual eventually causes the formation of gametocytes inside the blood cells. With the insect bite, the male and female gametes will enter the insect's stomach and form the zygote. After developing in the stomach, the zygote first turns into an ookinete and then into an oocyst, and by passing through the stomach wall and tearing the sporozoites, it enters the salivary glands of the insect, and if another person is bitten by that insect, the parasite enters the body of that person. and this cycle continues between the insect and the human body. Stopping this cycle requires blocking one part of this cycle. Studies show that...
Proposing a Control Method for Malaria
, M.Sc. Thesis Sharif University of Technology ; Shahrokhi, Mohammad (Supervisor)
Abstract
In every year malaria has enormous fatality around the world, so this disease has to be controlled. In this thesis based on a model given in the literature[12], a model predictive controller has been designed and its performance has been compared with that of the optimal control. The simulation results show that in the case of model mismatch, the performance of model predictive control is superior. In model selection, it has been tried that a comprehensive model that has enough inputs for control to be selected. A linear time varying model is used to simulate the nonlinear behavior of the nonlinear system. The Least Squares method is used to update the model parameters
Optimization and Continuous Synthesis of Artemisinin Using Core-Shell Nano-Catalysts by Means of Micro-Rector
, Ph.D. Dissertation Sharif University of Technology ; Kazemeini, Mohammad (Supervisor)
Abstract
Artemisinin as a natural peroxide possess a high anti parasite, and antivirus (Covid-19) properties which could be synthesized through the photooxygenation of dihydroartemisinic acid. This production possesses a lot of difficulties, for example, homogeneous catalyst is used for the photooxygenation reaction which makes photocatalyst and solvent non-reusable. In addition, separation of products from solvent and photocatalysts is difficult. Photooxygenation needs high pressure and low temperature which is very costly. Besides, because of several by-products which are producing during photooxygenation and protonation reactions, Artemisinin yield decreases. The aim of this study is to optimize...
Design, Expression, and Evaluation of Nanoparticle Structure Containing Malaria Vaccine Candidate Antigen by Self-assembled Peptide Nanoparticles (SAPNs) and Confirmation of its Antigenicity Using Serum of Malaria Patients
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Abouei Mehrizi, Akram (Supervisor) ; Sardari, Soroush (Co-Supervisor) ; Zakeri, Sedigheh (Co-Supervisor)
Abstract
Malaria is one of the most important infectious diseases in the tropical and subtropical regions of the world and is caused in humans by the bite of the female Anopheles mosquito of five species of Plasmodium. According to the World Health Organization, about 229 million people worldwide were infected in 2019 by the disease, and 409,000 people died from the disease. Resistance of the parasite against drugs and resistance of vectors to insecticides and larvicides, which prevents the elimination and eradication of malaria, shows the need for new strategies, such as having an effective vaccine against this disease. In the second generation of vaccines, to develop malaria vaccines, recombinant...