Search for: mechanobiology
0.005 seconds

    A Mechanobiological model for damage-induced growth in arterial tissue with application to in-stent restenosis

    , Article Journal of the Mechanics and Physics of Solids ; Volume 101 , 2017 , Pages 311-327 ; 00225096 (ISSN) Fereidoonnezhad, B ; Naghdabadi, R ; Sohrabpour, S ; Holzapfel, G. A ; Sharif University of Technology
    Elsevier Ltd  2017
    In-stent restenosis (ISR) is one of the main drawbacks of stent implementation which limits the long-term success of the procedure. Morphological changes occurring within the arterial wall due to stent-induced mechanical injury are a major cause for activation of vascular smooth muscle cells (VSMCs), and the subsequent development of ISR. Considering the theory of volumetric mass growth and adopting a multiplicative decomposition of the deformation gradient into an elastic part and a growth part, we present a mechanobiological model for ISR. An evolution equation is developed for mass growth of the neointima, in which the activation of VSMCs due to stent-induced damage (injury) and the... 

    A microfabricated platform for the study of chondrogenesis under different compressive loads

    , Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 78 , 2018 , Pages 404-413 ; 17516161 (ISSN) Kowsari Esfahan, R ; Jahanbakhsh, A ; Saidi, M. S ; Bonakdar, S ; Sharif University of Technology
    Elsevier Ltd  2018
    Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture. Numerical simulations were performed to evaluate and optimize the design. Results showed a...