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    Functional neuroimaging for addiction medicine: From mechanisms to practical considerations

    , Article Progress in Brain Research ; Volume 224 , 2016 , Pages 129-153 ; 00796123 (ISSN) ; 9780444637161 (ISBN) Ekhtiari, H ; Faghiri, A ; Oghabian, M. A ; Paulus, M. P ; Ekhtiari H. E ; Paulus M. P ; Sharif University of Technology
    Elsevier  2016
    During last 20 years, neuroimaging with functional magnetic resonance imaging (fMRI) in people with drug addictions has introduced a wide range of quantitative biomarkers from brain's regional or network level activities during different cognitive functions. These quantitative biomarkers could be potentially used for assessment, planning, prediction, and monitoring for "addiction medicine" during screening, acute intoxication, admission to a program, completion of an acute program, admission to a long-term program, and postgraduation follow-up. In this chapter, we have briefly reviewed main neurocognitive targets for fMRI studies associated with addictive behaviors, main study types using... 

    Clinical methods in medical family therapy

    , Book ; Mendenhall, Tai ; Lamson, Angela ; Hodgson, Jennifer ; Baird, Macaran A
    Springer International Publishing AG  2018

    Medical robotics: State-of-the-art applications and research challenges

    , Article International Journal of Healthcare Information Systems and Informatics ; Volume 8, Issue 2 , 2013 , Pages 1-14 ; 15553396 (ISSN) Mirbagheri, A ; Baniasad, M. A ; Farahmand, F ; Behzadipour, S ; Ahmadian, A ; Sharif University of Technology
    Many research and development projects are being performed worldwide to develop new products and applications for computer-assisted and medical robotic systems. In this paper, an overview of selected state-of-the-art applications of robotic technology in medicine is presented. Four key areas of image-guided surgery, virtual reality in medicine, surgical robots, and robotic rehabilitation systems, are studied. As well, current challenges in research and development are discussed. Copyright  

    The nano-based theranostics for respiratory complications of COVID-19

    , Article Drug Development and Industrial Pharmacy ; 2021 ; 03639045 (ISSN) Ghasemzad, M ; Hashemian, S. M. R ; Memarnejadian, A ; Akbarzadeh, I ; Hossein Khannazer, N ; Vosough, M ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    High morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made coronavirus disease 2019 (COVID-19) the leading challenge for health experts all over the world. Currently, there is no specific treatment for COVID-19; however, thanks to worldwide intense attempts, novel vaccines such as mRNA-1273 (Moderna TX, Inc.) and BNT162b2 (Biontech/Pfizer) were developed very fast and FDA approved them for emergency use. Nanomedicine-based drug delivery can be an advanced therapeutic strategy to deal with clinical complications of COVID-19. Given the fact that SARS-CoV-2 typically affects the respiratory tract, application of inhalable nanoparticles (NPs)... 

    Methaphysical Foundations of Modern and Trasitional Medicine

    , M.Sc. Thesis Sharif University of Technology Kamali Ardekani, Morteza (Author) ; Golshani, Mehdi (Supervisor) ; Monagemi, Alireza (Supervisor)
    Few years the traditional medicine in our society is considered: Traditional colleges have been established, Traditional medicine has been established and numerous media programs produced by experts in traditional medicine. All this indicates is that traditional medicine seek lost credibility and gain its rightful place in our society today. One of the most important aspects of the relationship between traditional medicine with modern medicine. On the one hand trying to make traditional medicine with modern medicine can be defined as complementary medicine. In this regard, first of all defined traditional medicine as a specialty, and efforts to rebuild the achievements of traditional... 

    Mechanical characteristics of SPG-178 hydrogels: Optimizing viscoelastic properties through microrheology and response surface methodology

    , Article Iranian Biomedical Journal ; Volume 24, Issue 2 , 2020 , Pages 110-118 Seyedkarimi, M. S ; Mirzadeh, H ; Mohammadi, A ; Bagheri Khoulenjani, S ; Sharif University of Technology
    Pasteur Institute of Iran  2020
    Background: SApeptides have growing applications in tissue engineering and regenerative medicine. The application of SApeptide-based hydrogels depends strongly on their viscoelastic properties. Optimizing the properties is of importance in tuning the characteristics of the hydrogels for a variety of applications. Methods: In this study, we employed statistical modeling, conducted with the RSM and particle tracking microrheology, to investigate the effects of self-assembling SPG-178 peptide and added NaCl salt concentrations and milieu type (DI water or blood serum) on the viscoelastic properties of SPG-178 hydrogels. A central composite RSM model was employed for finding the optimum value of... 

    Nanotechnology-Abetted astaxanthin formulations in multimodel therapeutic and biomedical applications

    , Article Journal of Medicinal Chemistry ; Volume 65, Issue 1 , 2022 , Pages 2-36 ; 00222623 (ISSN) Jafari, Z ; Bigham, A ; Sadeghi, S ; Dehdashti, S. M ; Rabiee, N ; Abedivash, A ; Bagherzadeh, M ; Nasseri, B ; Karimi Maleh, H ; Sharifi, E ; Varma, R. S ; Makvandi, P ; Sharif University of Technology
    American Chemical Society  2022
    Astaxanthin (AXT) is one of the most important fat-soluble carotenoids that have abundant and diverse therapeutic applications namely in liver disease, cardiovascular disease, cancer treatment, protection of the nervous system, protection of the skin and eyes against UV radiation, and boosting the immune system. However, due to its intrinsic reactivity, it is chemically unstable, and therefore, the design and production processes for this compound need to be precisely formulated. Nanoencapsulation is widely applied to protect AXT against degradation during digestion and storage, thus improving its physicochemical properties and therapeutic effects. Nanocarriers are delivery systems with many... 

    Improving the 3D Segmentation of Nodules in Lung CT Images

    , M.Sc. Thesis Sharif University of Technology Moradi, Puria (Author) ; Jamzad, Mansour (Supervisor) ; Beigy, Hamid (Co-Supervisor)
    Lung cancer is one of the most common types of cancers, and its early diagnosis can save many lives. Due to the high number of computed tomography (CT) images used to detect lung cancer, it is difficult to accurately and rapidly diagnose this disease. Doing so requires high expertise by radiologists. Therefore the demand for computer aided diagnosis systems in this area has been increased. The core of all lung cancer detection systems is the distinction between cancer and non-cancerous tissues. The main objective of this study is to present a new method based on 3D convolutional neural networks (CNN) that can perform false positives reduction operations while providing high sensitivity. In... 

    An Efficient Model For Considering the Effects Of Drug On Cancer Cells

    , M.Sc. Thesis Sharif University of Technology Nikahd, Mojtaba (Author) ; Habibi, Jafar (Supervisor)
    The development of technologies and some defects in medicine caused to emerge a new approach called precision medicine. Unlike the traditional medicine, medical experts do best treatment for each patient based on his genetic characteristics in this approach. Predicting drug response on cancer cell lines is one of the most vital challenges in this area. Various approaches have been proposed to construct predicting models while the substantial distinctions between resistant and sensitive cell lines had been neglected in them. Here, we propose a new approach for constructing the predictive model. In our approach, we utilized the distinctions between sensitive and resistant cell lines and also... 

    Automatic Classification of Masses in Mammographic Images using Sparse Representation

    , M.Sc. Thesis Sharif University of Technology Zarghami, Ali (Author) ; Manzouri, Mohammad Taghi (Supervisor)
    Computer Aided Diagnosis (CAD) systems are widely used in different medical tasks. Radiology is a branch of medicine which takes advantage of image processing techniques to help radiologists, analyse complicated radiologic images. Among all kind of medical imagingprocedures, utilization of screening mammographyisgetting very popularin detection of breast abnormalities. A typical CAD system for mammogram analysis uses image enhancement and segmentation as pre-processing phase, and feature extraction and classification for detection phase. In this thesis, we have studied different approaches in each level of image processing required in a mammogram mass classification systems, and introduced a... 

    Characterization of Tissue Structure of Natural Scaffolds Made of Rat Kidney

    , M.Sc. Thesis Sharif University of Technology Rezaiepour, Yashar (Author) ; Asgari, Sirius (Supervisor) ; Kajbafzadeh, Abdolmohammad (Supervisor)
    Recently, the deficiency of methods like organ donation and medicine made tissue engineering a prospective method in regeneration of tissues. Despite all of its advantageous like any other method, it has its own weak points. Its major disadvantage is the probability of rejection by the host body. Using proper material and controlling synthesis reactions by researchers decreased the rejection of synthetic scaffolds. But in the case of natural scaffolds due to the range of properties, many tests should be applied on the scaffold prior to implantation in order to evaluate functionality in body. In this research, SDS and TritonX100 has been used to decellulize kidney. Then using uniaxial... 

    A Novel Digital Dentistry Platform Based on Cloud Manufacturing Paradigm

    , Ph.D. Dissertation Sharif University of Technology Valizadeh, Siavash (Author) ; Houshmand, Mahmoud (Supervisor) ; Fatahi Valilai, Omid (Supervisor) ; Vasegh, Zahra (Supervisor)
    This thesis has developed a novel platform for digital dentistry which facilitates the interoperability among different digital components and improves digital workflow in a collaborative environment. The platform is inspired by the cloud manufacturing paradigm for enabling the interoperability and collaboration management and also applies the DICOM standard to improve the integration for the coordination among the different stakeholders for better sharing of their resources while they are geographically distributed. The paper has proposed the application of the PACS concept to include design, implant planning, process planning and production workstations. The paper has conducted a... 

    Improvement of PET Images Using Wavelet Method and its Comparison with Usual Clinical Method

    , M.Sc. Thesis Sharif University of Technology Mohammadi, Mohammad Sadegh (Author) ; Hosseini, Abolfazl (Supervisor)
    Positron emission tomography (PET) imaging is a cross-sectional imaging method in nuclear medicine. In recent years, there have been increasing interest in this method.PET imaging is very sensitive and the presence of noise in the results decreases the the image quality and precision of detection. Thus it is critical to to investigate noise in PET systems with noisy images, since it could decrease the system’s ability to detect tumors. The common method to decrease noise in nuclear medicine images is the Fourier transform (FT). The method has many applications in image processing and analysis. However, in the FT method, information regarding time and position are lost in the frequency... 

    Design a Microfluidics System for Drug Testing of Leukemia Patient's Bone Marrow Aspirate

    , M.Sc. Thesis Sharif University of Technology Rahimi, Ali (Author) ; Saidi, Mohammad Said (Supervisor)
    Cancer is one of the most causes of mortality in the world. Leukemia is a type of cancer initiated by the rapid proliferation of blood cells including WBCs, RBCs, and Platelets, that classified into four general types of AML, ALL, CML, and CLL. The main treatment of leukemia is chemotherapy. Because of many problems that patients have with this treatment and not so good results of chemotherapy, we design a microfluidic chip that can perform personalized medicine treatment for leukemia patients.This microchip consists of two main parts, Concentration Gradient Generator (CGG), and cell culture. CGG system is a tree CGG with two inlets and four outlets, which makes a linear concentration of... 

    A low cost, efficient method for chip fabrication in cell analysis

    , Article 2016 23rd Iranian Conference on Biomedical Engineering and 2016 1st International Iranian Conference on Biomedical Engineering, ICBME 2016, 23 November 2016 through 25 November 2016 ; 2017 , Pages 93-96 ; 9781509034529 (ISBN) Rahmani, A ; Mohammadi, A ; Kalhor, H ; Sharif University of Technology
    in recent decades, DEP due to its high efficiency has been exploited widely in separation and manipulation of bioparticles. In the present work a simple, low-cost, and efficient procedure for fabrication of microfluidic chips applied in medicine and biochemistry has been presented. In this method, electrodes are not in direct contact with biological samples which results in elimination of conventional systems' cons. Efficacy of the designed system has been evaluated by injecting samples containing yeast and Ecoli cells into the system and analyzing their trajectory. Experimental results demonstrate that precise adjustment of voltage and frequency can lead to the desired separation in this... 

    Coordination variability during walking and running in individuals with and without patellofemoral pain part 2: proximal segments coordination variability

    , Article Journal of Medical and Biological Engineering ; Volume 41, Issue 3 , 2021 , Pages 305-313 ; 16090985 (ISSN) Haghighat, F ; Rezaie, M ; Ebrahimi, S ; Shokouhyan, S. M ; Motealleh, A ; Parnianpour, M ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2021
    Purpose: There is a scarcity of studies evaluating the variability of couplings between proximal segments (trunk, pelvis, and thigh) in individuals with patellofemoral pain (PFP) while emerging evidence has suggested that aberrant motions of trunk and pelvis can have a contributory role in the etiology of PFP. The purpose of this study was, therefore, to evaluate the trunk, pelvis, and thigh intersegmental coordination variability in PFP compared with healthy individuals. Methods: Thirty-four participants (17 with PFP and 17 healthy controls) walked (at preferred speed) and ran (at preferred and fixed speed) on a treadmill each trial for 30 seconds. Three-dimensional kinematics were recorded... 

    Developing a hybrid artificial intelligence model for outpatient visits forecasting in hospitals

    , Article Applied Soft Computing Journal ; Volume 12, Issue 2 , 2012 , Pages 700-711 ; 15684946 (ISSN) Hadavandi, E ; Shavandi, H ; Ghanbari, A ; Abbasian Naghneh, S ; Sharif University of Technology
    Accurate forecasting of outpatient visits aids in decision-making and planning for the future and is the foundation for greater and better utilization of resources and increased levels of outpatient care. It provides the ability to better manage the ways in which outpatient's needs and aspirations are planned and delivered. This study presents a hybrid artificial intelligence (AI) model to develop a Mamdani type fuzzy rule based system to forecast outpatient visits with high accuracy. The hybrid model uses genetic algorithm for evolving knowledge base of fuzzy system. Actually it extracts useful patterns of information with a descriptive rule induction approach based on Genetic Fuzzy Systems... 

    Advances in tannic acid-incorporated biomaterials: Infection treatment, regenerative medicine, cancer therapy, and biosensing

    , Article Chemical Engineering Journal ; Volume 432 , 2022 ; 13858947 (ISSN) Bigham, A ; Rahimkhoei, V ; Abasian, P ; Delfi, M ; Naderi, J ; Ghomi, M ; Dabbagh Moghaddam, F ; Waqar, T ; Nuri Ertas, Y ; Sharifi, S ; Rabiee, N ; Ersoy, S ; Maleki, A ; Nazarzadeh Zare, E ; Sharifi, E ; Jabbari, E ; Makvandi, P ; Akbari, A ; Sharif University of Technology
    Elsevier B.V  2022
    Polyphenol-based materials have attracted wide-spread interest from academic and industrial communities because of their unique structure and physicochemical properties. Tannic acid (TA), as a polyphenolic phytochemical with high level of galloyl groups, interacts with various substances (proteins, polysaccharides, and metals) through several modes including hydrogen bonding, hydrophobic and electrostatic interactions. Such hybrid or hybrid-like systems allow the preparation of various advanced materials with promising applications in medicine. In this review, we highlight the recent advances of TA-incorporated materials in medical applications including drug delivery, tissue engineering,... 

    Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types

    , Article BMC Bioinformatics ; Volume 23, Issue 1 , 2022 ; 14712105 (ISSN) Ghareyazi, A ; Kazemi, A ; Hamidieh, K ; Dashti, H ; Tahaei, M. S ; Rabiee, H. R ; Alinejad Rokny, H ; Dehzangi, I ; Sharif University of Technology
    BioMed Central Ltd  2022
    Background: The advent of high throughput sequencing has enabled researchers to systematically evaluate the genetic variations in cancer, identifying many cancer-associated genes. Although cancers in the same tissue are widely categorized in the same group, they demonstrate many differences concerning their mutational profiles. Hence, there is no definitive treatment for most cancer types. This reveals the importance of developing new pipelines to identify cancer-associated genes accurately and re-classify patients with similar mutational profiles. Classification of cancer patients with similar mutational profiles may help discover subtypes of cancer patients who might benefit from specific... 

    Microfluidic-based droplets for advanced regenerative medicine: current challenges and future trends

    , Article Biosensors ; Volume 12, Issue 1 , 2022 ; 20796374 (ISSN) Nazari, H ; Heirani Tabasi, A ; Ghorbani, S ; Eyni, H ; Razavi Bazaz, S ; Khayati, M ; Gheidari, F ; Moradpour, K ; Kehtari, M ; Ahmadi Tafti, S.M ; Ahmadi Tafti, S. H ; Warkiani, M. E ; Sharif University of Technology
    MDPI  2022
    Microfluidics is a promising approach for the facile and large-scale fabrication of monodispersed droplets for various applications in biomedicine. This technology has demonstrated great potential to address the limitations of regenerative medicine. Microfluidics provides safe, accurate, reliable, and cost-effective methods for encapsulating different stem cells, gametes, biomaterials, biomolecules, reagents, genes, and nanoparticles inside picoliter-sized droplets or droplet-derived microgels for different applications. Moreover, microenvironments made using such droplets can mimic niches of stem cells for cell therapy purposes, simulate native extracellular matrix (ECM) for tissue...